HCSGD entry for AGXT
1. General information
| Official gene symbol | AGXT |
|---|---|
| Entrez ID | 189 |
| Gene full name | alanine-glyoxylate aminotransferase |
| Other gene symbols | AGT AGT1 AGXT1 PH1 SPAT SPT TLH6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004760 | Serine-pyruvate transaminase activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0005782 | Peroxisomal matrix | IDA TAS | cellular_component |
| GO:0006625 | Protein targeting to peroxisome | IMP | biological_process |
| GO:0008453 | Alanine-glyoxylate transaminase activity | IDA TAS | molecular_function |
| GO:0008483 | Transaminase activity | IDA | molecular_function |
| GO:0009436 | Glyoxylate catabolic process | IDA | biological_process |
| GO:0016597 | Amino acid binding | IDA | molecular_function |
| GO:0019265 | Glycine biosynthetic process, by transamination of glyoxylate | IDA | biological_process |
| GO:0019448 | L-cysteine catabolic process | IDA | biological_process |
| GO:0030170 | Pyridoxal phosphate binding | IDA IMP | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0042853 | L-alanine catabolic process | IDA | biological_process |
| GO:0042866 | Pyruvate biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046487 | Glyoxylate metabolic process | IMP TAS | biological_process |
| GO:0046724 | Oxalic acid secretion | IEA | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8507820410 | 0.6977994947 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0371520342 |
| GSE13712_SHEAR | Down | -0.0880004318 |
| GSE13712_STATIC | Up | 0.0273790827 |
| GSE19018 | Up | 0.0339338229 |
| GSE19899_A1 | Down | -0.0305424339 |
| GSE19899_A2 | Down | -0.0132255990 |
| PubMed_21979375_A1 | Down | -0.0009183236 |
| PubMed_21979375_A2 | Down | -0.0903302467 |
| GSE35957 | Up | 0.0402289941 |
| GSE36640 | Down | -0.0579551562 |
| GSE54402 | Down | -0.0760248922 |
| GSE9593 | Down | -0.0487193357 |
| GSE43922 | Down | -0.0364813414 |
| GSE24585 | Up | 0.0464356585 |
| GSE37065 | Down | -0.0392852986 |
| GSE28863_A1 | Down | -0.2167677994 |
| GSE28863_A2 | Up | 0.0511832443 |
| GSE28863_A3 | Up | 0.3852466413 |
| GSE28863_A4 | Up | 0.2175636710 |
| GSE48662 | Down | -0.0147111755 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glycine | DB00145 | NUTR00028 |
| L-Alanine | DB00160 | NUTR00013 |
| Aminooxyacetic acid | DB02079 | EXPT00528 |
| N'-Pyridoxyl-Lysine-5'-Monophosphate | DB04083 | EXPT02040 |
| 4-(2-AMINOPHENYL)-4-OXOBUTANOIC ACID | DB08060 | - |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
