HCSGD entry for HBEGF
1. General information
| Official gene symbol | HBEGF |
|---|---|
| Entrez ID | 1839 |
| Gene full name | heparin-binding EGF-like growth factor |
| Other gene symbols | DTR DTS DTSF HEGFL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005154 | Epidermal growth factor receptor binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA ISS TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | ISS TAS | cellular_component |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | IMP TAS | biological_process |
| GO:0007517 | Muscle organ development | TAS | biological_process |
| GO:0008016 | Regulation of heart contraction | IEA | biological_process |
| GO:0008083 | Growth factor activity | IDA | molecular_function |
| GO:0008201 | Heparin binding | IMP | molecular_function |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0009986 | Cell surface | IDA NAS | cellular_component |
| GO:0030307 | Positive regulation of cell growth | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IMP | biological_process |
| GO:0035313 | Wound healing, spreading of epidermal cells | IEA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0048661 | Positive regulation of smooth muscle cell proliferation | IEA | biological_process |
| GO:0051545 | Negative regulation of elastin biosynthetic process | IEA | biological_process |
| GO:0051549 | Positive regulation of keratinocyte migration | IEA | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IMP | biological_process |
| GO:0090303 | Positive regulation of wound healing | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0334033357 | 0.6586174879 | 0.4200096897 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4924473567 |
| GSE13712_SHEAR | Up | 0.3551904035 |
| GSE13712_STATIC | Up | 0.1084473976 |
| GSE19018 | Down | -1.2445606145 |
| GSE19899_A1 | Up | 0.0205585544 |
| GSE19899_A2 | Up | 0.6856586249 |
| PubMed_21979375_A1 | Up | 0.3818416178 |
| PubMed_21979375_A2 | Down | -0.0909247305 |
| GSE35957 | Down | -0.2862272896 |
| GSE36640 | Up | 0.3209087445 |
| GSE54402 | Up | 0.6364087865 |
| GSE9593 | Up | 0.1124267353 |
| GSE43922 | Up | 0.3286652663 |
| GSE24585 | Up | 0.1623431306 |
| GSE37065 | Up | 0.2915276608 |
| GSE28863_A1 | Down | -0.1273643628 |
| GSE28863_A2 | Up | 0.2308416741 |
| GSE28863_A3 | Up | 0.2995702659 |
| GSE28863_A4 | Up | 0.0259256311 |
| GSE48662 | Up | 0.8466677132 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-194-5p | MIMAT0000460 | MIRT005891 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20979124 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT006659 | Luciferase reporter assay//Microarray//qRT-PCR//Western blot | Functional MTI | 21853268 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT006659 | Luciferase reporter assay | Functional MTI | 22310291 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT006659 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024470 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026939 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027820 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21507328 | Besides the contribution of reactive oxygen species and telomere dysfunction to aging, it is the aim of this mini-review, to compare distinct changes to extracellular signals by certain matrix metalloproteinases including MMP-7 and associated growth factor pathways mediated by HB-EGF activation in young and aging HMEC |
| 20300111 | Jun(d/d) mouse embryonic fibroblasts (MEFs) exhibit early senescence, which can be rescued by EGF and HB-EGF stimulation, probably through activation of Akt signaling |
| 19682489 | RNAi experiments revealed both the ECM metalloproteinase MMP-7 and the growth factor HB-EGF as potential effectors of an increased tropoelastin expression |
| 19682489 | Moreover, co-localization of MMP-7 and HB-EGF as well as a concomittant downstream signaling via Fra-1 indicated a possible association between the reduced MMP-7 enzyme activity and an impaired HB-EGF processing, resulting in an enhanced tropoelastin synthesis during senescence of HMEC |
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