HCSGD entry for HBEGF

1. General information

Official gene symbolHBEGF
Entrez ID1839
Gene full nameheparin-binding EGF-like growth factor
Other gene symbolsDTR DTS DTSF HEGFL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005154Epidermal growth factor receptor bindingIEAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDA ISS TAScellular_component
GO:0005887Integral component of plasma membraneISS TAScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayIMP TASbiological_process
GO:0007517Muscle organ developmentTASbiological_process
GO:0008016Regulation of heart contractionIEAbiological_process
GO:0008083Growth factor activityIDAmolecular_function
GO:0008201Heparin bindingIMPmolecular_function
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0009986Cell surfaceIDA NAScellular_component
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0035313Wound healing, spreading of epidermal cellsIEAbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0051545Negative regulation of elastin biosynthetic processIEAbiological_process
GO:0051549Positive regulation of keratinocyte migrationIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0090303Positive regulation of wound healingIMPbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03340333570.65861748790.42000968971.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4924473567
GSE13712_SHEARUp0.3551904035
GSE13712_STATICUp0.1084473976
GSE19018Down-1.2445606145
GSE19899_A1Up0.0205585544
GSE19899_A2Up0.6856586249
PubMed_21979375_A1Up0.3818416178
PubMed_21979375_A2Down-0.0909247305
GSE35957Down-0.2862272896
GSE36640Up0.3209087445
GSE54402Up0.6364087865
GSE9593Up0.1124267353
GSE43922Up0.3286652663
GSE24585Up0.1623431306
GSE37065Up0.2915276608
GSE28863_A1Down-0.1273643628
GSE28863_A2Up0.2308416741
GSE28863_A3Up0.2995702659
GSE28863_A4Up0.0259256311
GSE48662Up0.8466677132

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-194-5pMIMAT0000460MIRT005891Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20979124
hsa-miR-132-3pMIMAT0000426MIRT006659Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI21853268
hsa-miR-132-3pMIMAT0000426MIRT006659Luciferase reporter assayFunctional MTI22310291
hsa-miR-132-3pMIMAT0000426MIRT006659MicroarrayFunctional MTI (Weak)17612493
hsa-miR-215-5pMIMAT0000272MIRT024470MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026939MicroarrayFunctional MTI (Weak)19074876
hsa-miR-98-5pMIMAT0000096MIRT027820MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21507328Besides the contribution of reactive oxygen species and telomere dysfunction to aging, it is the aim of this mini-review, to compare distinct changes to extracellular signals by certain matrix metalloproteinases including MMP-7 and associated growth factor pathways mediated by HB-EGF activation in young and aging HMEC
20300111Jun(d/d) mouse embryonic fibroblasts (MEFs) exhibit early senescence, which can be rescued by EGF and HB-EGF stimulation, probably through activation of Akt signaling
19682489RNAi experiments revealed both the ECM metalloproteinase MMP-7 and the growth factor HB-EGF as potential effectors of an increased tropoelastin expression
19682489Moreover, co-localization of MMP-7 and HB-EGF as well as a concomittant downstream signaling via Fra-1 indicated a possible association between the reduced MMP-7 enzyme activity and an impaired HB-EGF processing, resulting in an enhanced tropoelastin synthesis during senescence of HMEC
Entries Per Page
Displaying Page of