HCSGD entry for DNM2

1. General information

Official gene symbolDNM2
Entrez ID1785
Gene full namedynamin 2
Other gene symbolsCMT2M CMTDI1 CMTDIB DI-CMTB DYN2 DYNII
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleNASbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0003924GTPase activityIEA NAS TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEA NASmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIDA IEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006184GTP catabolic processNAS TASbiological_process
GO:0006355Regulation of transcription, DNA-templatedNASbiological_process
GO:0006892Post-Golgi vesicle-mediated transportTASbiological_process
GO:0006897EndocytosisIEA NASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0008017Microtubule bindingNASmolecular_function
GO:0014069Postsynaptic densityIEAcellular_component
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0019899Enzyme bindingNASmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030496MidbodyIEAcellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0031623Receptor internalizationIMPbiological_process
GO:0033572Transferrin transportIMPbiological_process
GO:0043065Positive regulation of apoptotic processNASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045211Postsynaptic membraneIDAcellular_component
GO:0045893Positive regulation of transcription, DNA-templatedNASbiological_process
GO:0046209Nitric oxide metabolic processTASbiological_process
GO:0048489Synaptic vesicle transportNASbiological_process
GO:0050999Regulation of nitric-oxide synthase activityTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24460831660.84480623080.93273324641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0282557239
GSE13712_SHEARDown-0.1149667634
GSE13712_STATICDown-0.0787221897
GSE19018Down-0.0962904715
GSE19899_A1Down-0.1001893540
GSE19899_A2Up0.2659859845
PubMed_21979375_A1Up0.8879573530
PubMed_21979375_A2Up0.8529567136
GSE35957Up0.0074364966
GSE36640Up0.0481514892
GSE54402Up0.1565345671
GSE9593Down-0.0232812241
GSE43922Down-0.0655833157
GSE24585Up0.0122092523
GSE37065Down-0.1065336263
GSE28863_A1Up0.2940017398
GSE28863_A2Up0.2150078280
GSE28863_A3Down-0.0791715323
GSE28863_A4Up0.0487527657
GSE48662Up0.4278621863

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT002670MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT002670Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-130a-3pMIMAT0000425MIRT007139qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-615-3pMIMAT0003283MIRT040188CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049062CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.