HCSGD entry for DDX11

1. General information

Official gene symbolDDX11
Entrez ID1663
Gene full nameDEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Other gene symbolsCHL1 CHLR1 KRG2 WABS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000070Mitotic sister chromatid segregationTASbiological_process
GO:0000084Mitotic S phaseTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000922Spindle poleIDAcellular_component
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003678DNA helicase activityTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIEAmolecular_function
GO:0004386Helicase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIEAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007062Sister chromatid cohesionIDAbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016817Hydrolase activity, acting on acid anhydridesIEAmolecular_function
GO:0030496MidbodyIDAcellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0032508DNA duplex unwindingIEA TASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94536378940.03348338590.99999024730.3456141961

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0895369688
GSE13712_SHEARUp0.1726980367
GSE13712_STATICDown-0.3803604541
GSE19018Down-0.0106143593
GSE19899_A1Down-0.0713727025
GSE19899_A2Down-0.5057723158
PubMed_21979375_A1Down-0.2021560954
PubMed_21979375_A2Down-0.4627208751
GSE35957Down-1.0017913710
GSE36640Down-1.6605600508
GSE54402Down-0.0762372275
GSE9593Down-0.3929788653
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.1570594708
GSE28863_A2Down-0.0036756647
GSE28863_A3Up0.4205058790
GSE28863_A4Up0.1707437733
GSE48662Down-0.1678369255

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037623CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040191CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043115CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.