HCSGD entry for DDX11

1. General information

Official gene symbolDDX11
Entrez ID1663
Gene full nameDEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Other gene symbolsCHL1 CHLR1 KRG2 WABS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000070Mitotic sister chromatid segregationTASbiological_process
GO:0000084Mitotic S phaseTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000922Spindle poleIDAcellular_component
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003678DNA helicase activityTASmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0004003ATP-dependent DNA helicase activityIEAmolecular_function
GO:0004386Helicase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIEAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0007062Sister chromatid cohesionIDAbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016817Hydrolase activity, acting on acid anhydridesIEAmolecular_function
GO:0030496MidbodyIDAcellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0032508DNA duplex unwindingIEA TASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94536378940.03348338590.99999024730.3456141961

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0895369688
GSE13712_SHEARUp0.1726980367
GSE13712_STATICDown-0.3803604541
GSE19018Down-0.0106143593
GSE19899_A1Down-0.0713727025
GSE19899_A2Down-0.5057723158
PubMed_21979375_A1Down-0.2021560954
PubMed_21979375_A2Down-0.4627208751
GSE35957Down-1.0017913710
GSE36640Down-1.6605600508
GSE54402Down-0.0762372275
GSE9593Down-0.3929788653
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.1570594708
GSE28863_A2Down-0.0036756647
GSE28863_A3Up0.4205058790
GSE28863_A4Up0.1707437733
GSE48662Down-0.1678369255

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037623CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040191CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043115CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.