HCSGD entry for RNF168
1. General information
| Official gene symbol | RNF168 |
|---|---|
| Entrez ID | 165918 |
| Gene full name | ring finger protein 168, E3 ubiquitin protein ligase |
| Other gene symbols | hRNF168 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0006302 | Double-strand break repair | IDA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA | biological_process |
| GO:0031491 | Nucleosome binding | IDA | molecular_function |
| GO:0035518 | Histone H2A monoubiquitination | IDA | biological_process |
| GO:0035861 | Site of double-strand break | IDA | cellular_component |
| GO:0036297 | Interstrand cross-link repair | TAS | biological_process |
| GO:0036351 | Histone H2A-K13 ubiquitination | IDA | biological_process |
| GO:0036352 | Histone H2A-K15 ubiquitination | IDA | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0043130 | Ubiquitin binding | IDA | molecular_function |
| GO:0045190 | Isotype switching | ISS | biological_process |
| GO:0045739 | Positive regulation of DNA repair | IDA | biological_process |
| GO:0045900 | Negative regulation of translational elongation | IMP | biological_process |
| GO:0070530 | K63-linked polyubiquitin binding | IDA | molecular_function |
| GO:0070534 | Protein K63-linked ubiquitination | IDA | biological_process |
| GO:0070535 | Histone H2A K63-linked ubiquitination | IDA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3339344820 | 0.2375537214 | 0.9999902473 | 0.9382730342 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3143100501 |
| GSE13712_SHEAR | Up | 0.0808527963 |
| GSE13712_STATIC | Down | -0.2776288057 |
| GSE19018 | Down | -0.4874275295 |
| GSE19899_A1 | Down | -0.3427242315 |
| GSE19899_A2 | Down | -0.5017917026 |
| PubMed_21979375_A1 | Up | 0.0349828970 |
| PubMed_21979375_A2 | Down | -0.1603180512 |
| GSE35957 | Down | -0.1571398977 |
| GSE36640 | Down | -0.9237729685 |
| GSE54402 | Up | 0.4149274555 |
| GSE9593 | Down | -0.2563706536 |
| GSE43922 | Up | 0.0217582779 |
| GSE24585 | Up | 0.1625179301 |
| GSE37065 | Up | 0.1042228748 |
| GSE28863_A1 | Up | 0.8548600340 |
| GSE28863_A2 | Up | 0.6126978907 |
| GSE28863_A3 | Up | 0.1532201520 |
| GSE28863_A4 | Down | -0.1022343365 |
| GSE48662 | Down | -0.0236655688 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040572 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
