HCSGD entry for RNF168

1. General information

Official gene symbolRNF168
Entrez ID165918
Gene full namering finger protein 168, E3 ubiquitin protein ligase
Other gene symbolshRNF168
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0003682Chromatin bindingIDAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0006302Double-strand break repairIDAbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010212Response to ionizing radiationIDAbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0031491Nucleosome bindingIDAmolecular_function
GO:0035518Histone H2A monoubiquitinationIDAbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0036297Interstrand cross-link repairTASbiological_process
GO:0036351Histone H2A-K13 ubiquitinationIDAbiological_process
GO:0036352Histone H2A-K15 ubiquitinationIDAbiological_process
GO:0042393Histone bindingIDAmolecular_function
GO:0043130Ubiquitin bindingIDAmolecular_function
GO:0045190Isotype switchingISSbiological_process
GO:0045739Positive regulation of DNA repairIDAbiological_process
GO:0045900Negative regulation of translational elongationIMPbiological_process
GO:0070530K63-linked polyubiquitin bindingIDAmolecular_function
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
GO:0070535Histone H2A K63-linked ubiquitinationIDA IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.33393448200.23755372140.99999024730.9382730342

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3143100501
GSE13712_SHEARUp0.0808527963
GSE13712_STATICDown-0.2776288057
GSE19018Down-0.4874275295
GSE19899_A1Down-0.3427242315
GSE19899_A2Down-0.5017917026
PubMed_21979375_A1Up0.0349828970
PubMed_21979375_A2Down-0.1603180512
GSE35957Down-0.1571398977
GSE36640Down-0.9237729685
GSE54402Up0.4149274555
GSE9593Down-0.2563706536
GSE43922Up0.0217582779
GSE24585Up0.1625179301
GSE37065Up0.1042228748
GSE28863_A1Up0.8548600340
GSE28863_A2Up0.6126978907
GSE28863_A3Up0.1532201520
GSE28863_A4Down-0.1022343365
GSE48662Down-0.0236655688

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-92b-3pMIMAT0003218MIRT040572CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.