HCSGD entry for DDX6

1. General information

Official gene symbolDDX6
Entrez ID1656
Gene full nameDEAD (Asp-Glu-Ala-Asp) box helicase 6
Other gene symbolsHLR2 P54 RCK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000932Cytoplasmic mRNA processing bodyIDAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0003724RNA helicase activityTASmolecular_function
GO:0004386Helicase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016442RISC complexIDAcellular_component
GO:0033962Cytoplasmic mRNA processing body assemblyIDAbiological_process
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05902849440.93995732680.52663012541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3270238321
GSE13712_SHEARUp0.1420151675
GSE13712_STATICUp0.1056328598
GSE19018Down-0.3116710874
GSE19899_A1Up0.0981197114
GSE19899_A2Up0.0628264611
PubMed_21979375_A1Up0.4859197851
PubMed_21979375_A2Up0.1540791376
GSE35957Up0.5592987876
GSE36640Down-0.1789679434
GSE54402Down-0.0133269786
GSE9593Up0.2026027593
GSE43922Up0.0315406063
GSE24585Up0.1368788553
GSE37065Up0.0348908753
GSE28863_A1Up0.4352613075
GSE28863_A2Up0.2726933905
GSE28863_A3Down-0.0770793871
GSE28863_A4Up0.0856967634
GSE48662Up0.6344074266

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

D-tartaric acidDB01694 EXPT03007

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-425-5pMIMAT0003393MIRT016661SequencingFunctional MTI (Weak)20371350
hsa-miR-130b-3pMIMAT0000691MIRT020341SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022934Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023959ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT030008SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031272SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031272CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT037013CLASHFunctional MTI (Weak)23622248
hsa-miR-505-3pMIMAT0002876MIRT041022CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041644CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043327CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049444CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051097CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-130a-3pMIMAT0000425NAhsa-miR-130a{Western blot}{overexpression by miRNA precursor transfection}21486751
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.