HCSGD entry for DDX6

1. General information

Official gene symbolDDX6
Entrez ID1656
Gene full nameDEAD (Asp-Glu-Ala-Asp) box helicase 6
Other gene symbolsHLR2 P54 RCK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000288Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decayTASbiological_process
GO:0000932Cytoplasmic mRNA processing bodyIDAcellular_component
GO:0003723RNA bindingIEAmolecular_function
GO:0003724RNA helicase activityTASmolecular_function
GO:0004386Helicase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0016442RISC complexIDAcellular_component
GO:0033962Cytoplasmic mRNA processing body assemblyIDAbiological_process
GO:0043928Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05902849440.93995732680.52663012541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3270238321
GSE13712_SHEARUp0.1420151675
GSE13712_STATICUp0.1056328598
GSE19018Down-0.3116710874
GSE19899_A1Up0.0981197114
GSE19899_A2Up0.0628264611
PubMed_21979375_A1Up0.4859197851
PubMed_21979375_A2Up0.1540791376
GSE35957Up0.5592987876
GSE36640Down-0.1789679434
GSE54402Down-0.0133269786
GSE9593Up0.2026027593
GSE43922Up0.0315406063
GSE24585Up0.1368788553
GSE37065Up0.0348908753
GSE28863_A1Up0.4352613075
GSE28863_A2Up0.2726933905
GSE28863_A3Down-0.0770793871
GSE28863_A4Up0.0856967634
GSE48662Up0.6344074266

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

D-tartaric acidDB01694 EXPT03007

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-425-5pMIMAT0003393MIRT016661SequencingFunctional MTI (Weak)20371350
hsa-miR-130b-3pMIMAT0000691MIRT020341SequencingFunctional MTI (Weak)20371350
hsa-miR-124-3pMIMAT0000422MIRT022934Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023959ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT030008SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031272SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031272CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT037013CLASHFunctional MTI (Weak)23622248
hsa-miR-505-3pMIMAT0002876MIRT041022CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041644CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043327CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049444CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051097CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-130a-3pMIMAT0000425NAhsa-miR-130a{Western blot}{overexpression by miRNA precursor transfection}21486751
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.