HCSGD entry for DDX5

1. General information

Official gene symbolDDX5
Entrez ID1655
Gene full nameDEAD (Asp-Glu-Ala-Asp) box helicase 5
Other gene symbolsG17P1 HLR1 HUMP68 p68
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000381Regulation of alternative mRNA splicing, via spliceosomeIDAbiological_process
GO:0000398MRNA splicing, via spliceosomeICbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003712Transcription cofactor activityIEAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0003724RNA helicase activityIEA IMP NASmolecular_function
GO:0004004ATP-dependent RNA helicase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0016049Cell growthNASbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0030331Estrogen receptor bindingIDAmolecular_function
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0033148Positive regulation of intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0036002Pre-mRNA bindingIDAmolecular_function
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0045069Regulation of viral genome replicationIEAbiological_process
GO:0045667Regulation of osteoblast differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048306Calcium-dependent protein bindingIEAmolecular_function
GO:0050681Androgen receptor bindingIDAmolecular_function
GO:0060765Regulation of androgen receptor signaling pathwayIMPbiological_process
GO:0071013Catalytic step 2 spliceosomeIDAcellular_component
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIMPbiological_process
GO:2001014Regulation of skeletal muscle cell differentiationISSbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99380177040.00023888150.99999024730.0271017241

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1224208420
GSE13712_SHEARDown-0.3641929652
GSE13712_STATICDown-0.2666456363
GSE19018Down-1.7979006795
GSE19899_A1Down-0.4889147633
GSE19899_A2Down-1.4718407039
PubMed_21979375_A1Down-1.2943882614
PubMed_21979375_A2Down-0.6325479706
GSE35957Up0.7069629856
GSE36640Up0.4025577535
GSE54402Down-0.7169677156
GSE9593Down-0.3038987992
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-1.2505787862
GSE28863_A2Down-1.6786075614
GSE28863_A3Down-0.4975701657
GSE28863_A4Down-0.4689148291
GSE48662Down-0.7332173920

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002799Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-1MIMAT0000416MIRT002799pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-205-5pMIMAT0000266MIRT003236Luciferase reporter assayNon-Functional MTI20065103
hsa-miR-340-5pMIMAT0004692MIRT019588SequencingFunctional MTI (Weak)20371350
hsa-miR-130b-3pMIMAT0000691MIRT020195SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT028078SequencingFunctional MTI (Weak)20371350
hsa-miR-15b-5pMIMAT0000417MIRT046459CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049294CLASHFunctional MTI (Weak)23622248
hsa-miR-24-3pMIMAT0000080MIRT050373CLASHFunctional MTI (Weak)23622248
hsa-miR-23a-3pMIMAT0000078MIRT050394CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050507CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050662CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22370639The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1)
Entries Per Page
Displaying Page of