HCSGD entry for DDX5

1. General information

Official gene symbolDDX5
Entrez ID1655
Gene full nameDEAD (Asp-Glu-Ala-Asp) box helicase 5
Other gene symbolsG17P1 HLR1 HUMP68 p68
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000381Regulation of alternative mRNA splicing, via spliceosomeIDAbiological_process
GO:0000398MRNA splicing, via spliceosomeICbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003712Transcription cofactor activityIEAmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0003724RNA helicase activityIEA IMP NASmolecular_function
GO:0004004ATP-dependent RNA helicase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEA NAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0016049Cell growthNASbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0030331Estrogen receptor bindingIDAmolecular_function
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0033148Positive regulation of intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0036002Pre-mRNA bindingIDAmolecular_function
GO:0043517Positive regulation of DNA damage response, signal transduction by p53 class mediatorIMPbiological_process
GO:0045069Regulation of viral genome replicationIEAbiological_process
GO:0045667Regulation of osteoblast differentiationISSbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048306Calcium-dependent protein bindingIEAmolecular_function
GO:0050681Androgen receptor bindingIDAmolecular_function
GO:0060765Regulation of androgen receptor signaling pathwayIMPbiological_process
GO:0071013Catalytic step 2 spliceosomeIDAcellular_component
GO:0072332Intrinsic apoptotic signaling pathway by p53 class mediatorIMPbiological_process
GO:2001014Regulation of skeletal muscle cell differentiationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99380177040.00023888150.99999024730.0271017241

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1224208420
GSE13712_SHEARDown-0.3641929652
GSE13712_STATICDown-0.2666456363
GSE19018Down-1.7979006795
GSE19899_A1Down-0.4889147633
GSE19899_A2Down-1.4718407039
PubMed_21979375_A1Down-1.2943882614
PubMed_21979375_A2Down-0.6325479706
GSE35957Up0.7069629856
GSE36640Up0.4025577535
GSE54402Down-0.7169677156
GSE9593Down-0.3038987992
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-1.2505787862
GSE28863_A2Down-1.6786075614
GSE28863_A3Down-0.4975701657
GSE28863_A4Down-0.4689148291
GSE48662Down-0.7332173920

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002799Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-1MIMAT0000416MIRT002799pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-205-5pMIMAT0000266MIRT003236Luciferase reporter assayNon-Functional MTI20065103
hsa-miR-340-5pMIMAT0004692MIRT019588SequencingFunctional MTI (Weak)20371350
hsa-miR-130b-3pMIMAT0000691MIRT020195SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT028078SequencingFunctional MTI (Weak)20371350
hsa-miR-15b-5pMIMAT0000417MIRT046459CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049294CLASHFunctional MTI (Weak)23622248
hsa-miR-24-3pMIMAT0000080MIRT050373CLASHFunctional MTI (Weak)23622248
hsa-miR-23a-3pMIMAT0000078MIRT050394CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050507CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050662CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22370639The tumor-suppressive effect of ZNF331 is mediated at least by downregulation of genes involved in cell growth promotion (DSTN, EIF5A, GARS, DDX5, STAM, UQCRFS1 and SET) and migration/invasion (DSTN and ACTR3), and upregulation of genome-stability gene (SSBP1) and cellular senescence gene (PNPT1)
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