HCSGD entry for DDX1

1. General information

Official gene symbolDDX1
Entrez ID1653
Gene full nameDEAD (Asp-Glu-Ala-Asp) box helicase 1
Other gene symbolsDBP-RB UKVH5d
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000245Spliceosomal complex assemblyNASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIDAmolecular_function
GO:0003712Transcription cofactor activityIDAmolecular_function
GO:0003724RNA helicase activityTASmolecular_function
GO:0003725Double-stranded RNA bindingIEAmolecular_function
GO:0004518Nuclease activityIDAmolecular_function
GO:0004527Exonuclease activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006302Double-strand break repairIDAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006446Regulation of translational initiationNASbiological_process
GO:0007275Multicellular organismal developmentIEPbiological_process
GO:0008026ATP-dependent helicase activityIDAmolecular_function
GO:0008143Poly(A) bindingIDAmolecular_function
GO:0009615Response to virusIEAbiological_process
GO:0010494Cytoplasmic stress granuleIDAcellular_component
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0032508DNA duplex unwindingIDAbiological_process
GO:0033677DNA/RNA helicase activityIDAmolecular_function
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0071920Cleavage bodyIDAcellular_component
GO:0072669TRNA-splicing ligase complexIDAcellular_component
GO:0090305Nucleic acid phosphodiester bond hydrolysisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.94205005130.05848244750.99999024730.4548807624

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2943267931
GSE13712_SHEARDown-0.1772657049
GSE13712_STATICDown-0.0196818663
GSE19018Down-0.2706249571
GSE19899_A1Down-0.2446119070
GSE19899_A2Down-0.3220485121
PubMed_21979375_A1Down-0.0768512001
PubMed_21979375_A2Up0.1306754098
GSE35957Down-0.2639736917
GSE36640Down-0.1852278370
GSE54402Up0.0837044597
GSE9593Down-0.3322332451
GSE43922Down-0.2001972730
GSE24585Down-0.3654364006
GSE37065Down-0.1648160667
GSE28863_A1Up0.0342584052
GSE28863_A2Up0.4392184800
GSE28863_A3Down-0.6220678829
GSE28863_A4Down-0.1762317640
GSE48662Down-0.5074512232

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1260aMIMAT0005911MIRT035849CLASHFunctional MTI (Weak)23622248
hsa-miR-342-5pMIMAT0004694MIRT038224CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.