HCSGD entry for DCK
1. General information
| Official gene symbol | DCK |
|---|---|
| Entrez ID | 1633 |
| Gene full name | deoxycytidine kinase |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004137 | Deoxycytidine kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006139 | Nucleobase-containing compound metabolic process | IEA | biological_process |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006206 | Pyrimidine nucleobase metabolic process | TAS | biological_process |
| GO:0006220 | Pyrimidine nucleotide metabolic process | IDA | biological_process |
| GO:0008144 | Drug binding | IDA | molecular_function |
| GO:0009157 | Deoxyribonucleoside monophosphate biosynthetic process | IDA TAS | biological_process |
| GO:0009165 | Nucleotide biosynthetic process | EXP IDA TAS | biological_process |
| GO:0016773 | Phosphotransferase activity, alcohol group as acceptor | IEA | molecular_function |
| GO:0019206 | Nucleoside kinase activity | EXP | molecular_function |
| GO:0042803 | Protein homodimerization activity | IPI | molecular_function |
| GO:0043097 | Pyrimidine nucleoside salvage | TAS | biological_process |
| GO:0043101 | Purine-containing compound salvage | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9122080012 | 0.0006093537 | 0.9999902473 | 0.0463549133 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4533964074 |
| GSE13712_SHEAR | Down | -0.0000495453 |
| GSE13712_STATIC | Down | -0.0556398052 |
| GSE19018 | Up | 0.1448198386 |
| GSE19899_A1 | Down | -1.0742914091 |
| GSE19899_A2 | Down | -1.6790191242 |
| PubMed_21979375_A1 | Down | -0.4285932195 |
| PubMed_21979375_A2 | Down | -1.9921035195 |
| GSE35957 | Down | -0.5637826370 |
| GSE36640 | Down | -1.9765802021 |
| GSE54402 | Down | -0.3748730571 |
| GSE9593 | Down | -0.3624781574 |
| GSE43922 | Down | -0.7042906845 |
| GSE24585 | Up | 0.1173198683 |
| GSE37065 | Down | -0.3015187101 |
| GSE28863_A1 | Up | 1.0856154969 |
| GSE28863_A2 | Down | -0.7559631889 |
| GSE28863_A3 | Down | -0.1322006270 |
| GSE28863_A4 | Down | -0.5639601388 |
| GSE48662 | Down | -0.9722633022 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Fludarabine | DB01073 | APRD00594 |
| 2'-Deoxycytidine | DB02594 | EXPT01140 |
| CP-4055 | DB05494 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019296 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021886 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
