HCSGD entry for DAPK3

1. General information

Official gene symbolDAPK3
Entrez ID1613
Gene full namedeath-associated protein kinase 3
Other gene symbolsZIP ZIPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000775Chromosome, centromeric regionIEAcellular_component
GO:0000910CytokinesisTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005815Microtubule organizing centerIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIDA IMPbiological_process
GO:0006940Regulation of smooth muscle contractionTASbiological_process
GO:0007088Regulation of mitosisTASbiological_process
GO:0010506Regulation of autophagyTASbiological_process
GO:0016568Chromatin modificationIEAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0017148Negative regulation of translationIDAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043522Leucine zipper domain bindingIPImolecular_function
GO:0046777Protein autophosphorylationIDA TASbiological_process
GO:0071346Cellular response to interferon-gammaIDA IEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:0097190Apoptotic signaling pathwayIEAbiological_process
GO:2000145Regulation of cell motilityTASbiological_process
GO:2000249Regulation of actin cytoskeleton reorganizationTASbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90410194520.35102201280.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0274181058
GSE13712_SHEARDown-0.1007580892
GSE13712_STATICDown-0.0561513285
GSE19018Down-0.0199695228
GSE19899_A1Up0.0013198408
GSE19899_A2Down-0.0701147022
PubMed_21979375_A1Down-0.1573921410
PubMed_21979375_A2Up0.0078548570
GSE35957Up0.0055844337
GSE36640Up0.0929310290
GSE54402Down-0.0655914081
GSE9593Up0.2107313842
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.3573061910
GSE28863_A2Down-0.6833128448
GSE28863_A3Up0.3241086531
GSE28863_A4Up0.0283187068
GSE48662Down-0.0118953034

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONEDB04716 -
4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acidDB07125 -
(4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrileDB07242 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-5pMIMAT0000093MIRT048888CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051054CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.