HCSGD entry for DAPK3

1. General information

Official gene symbolDAPK3
Entrez ID1613
Gene full namedeath-associated protein kinase 3
Other gene symbolsZIP ZIPK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000775Chromosome, centromeric regionIEAcellular_component
GO:0000910CytokinesisTASbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005815Microtubule organizing centerIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006915Apoptotic processIDA IMPbiological_process
GO:0006940Regulation of smooth muscle contractionTASbiological_process
GO:0007088Regulation of mitosisTASbiological_process
GO:0010506Regulation of autophagyTASbiological_process
GO:0016568Chromatin modificationIEAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0017148Negative regulation of translationIDAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043522Leucine zipper domain bindingIPImolecular_function
GO:0046777Protein autophosphorylationIDA TASbiological_process
GO:0071346Cellular response to interferon-gammaIDA IEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIMPbiological_process
GO:0097190Apoptotic signaling pathwayIEAbiological_process
GO:2000145Regulation of cell motilityTASbiological_process
GO:2000249Regulation of actin cytoskeleton reorganizationTASbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90410194520.35102201280.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0274181058
GSE13712_SHEARDown-0.1007580892
GSE13712_STATICDown-0.0561513285
GSE19018Down-0.0199695228
GSE19899_A1Up0.0013198408
GSE19899_A2Down-0.0701147022
PubMed_21979375_A1Down-0.1573921410
PubMed_21979375_A2Up0.0078548570
GSE35957Up0.0055844337
GSE36640Up0.0929310290
GSE54402Down-0.0655914081
GSE9593Up0.2107313842
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.3573061910
GSE28863_A2Down-0.6833128448
GSE28863_A3Up0.3241086531
GSE28863_A4Up0.0283187068
GSE48662Down-0.0118953034

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONEDB04716 -
4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acidDB07125 -
(4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrileDB07242 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-5pMIMAT0000093MIRT048888CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT051054CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.