HCSGD entry for DAG1

1. General information

Official gene symbolDAG1
Entrez ID1605
Gene full namedystroglycan 1 (dystrophin-associated glycoprotein 1)
Other gene symbols156DAG A3a AGRNR DAG MDDGC7 MDDGC9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIEAmolecular_function
GO:0002011Morphogenesis of an epithelial sheetIEAbiological_process
GO:0002162Dystroglycan bindingIEAmolecular_function
GO:0003779Actin bindingIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005604Basement membraneIDA IEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005913Cell-cell adherens junctionIEAcellular_component
GO:0005925Focal adhesionIDA IEAcellular_component
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0006607NLS-bearing protein import into nucleusIDAbiological_process
GO:0007016Cytoskeletal anchoring at plasma membraneIEA IMPbiological_process
GO:0008307Structural constituent of muscleIMPmolecular_function
GO:0009279Cell outer membraneIEAcellular_component
GO:0015631Tubulin bindingIDAmolecular_function
GO:0016010Dystrophin-associated glycoprotein complexIDAcellular_component
GO:0016011Dystroglycan complexIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016340Calcium-dependent cell-matrix adhesionIEAbiological_process
GO:0017166Vinculin bindingIPImolecular_function
GO:0019048Modulation by virus of host morphology or physiologyIDAbiological_process
GO:0021682Nerve maturationIEAbiological_process
GO:0022011Myelination in peripheral nervous systemIEAbiological_process
GO:0030027LamellipodiumIDAcellular_component
GO:0030175FilopodiumIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033268Node of RanvierIEAcellular_component
GO:0034453Microtubule anchoringIMPbiological_process
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0042383SarcolemmaIEAcellular_component
GO:0043034CostamereIEAcellular_component
GO:0043237Laminin-1 bindingISSmolecular_function
GO:0043409Negative regulation of MAPK cascadeIMPbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051393Alpha-actinin bindingIDAmolecular_function
GO:0051898Negative regulation of protein kinase B signalingIMPbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0070938Contractile ringIDAcellular_component
GO:0071679Commissural neuron axon guidanceIEAbiological_process
GO:0071711Basement membrane organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06331453210.29979826370.54299638671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1852536690
GSE13712_SHEARDown-0.2235883779
GSE13712_STATICDown-0.1841555819
GSE19018Up0.7945254538
GSE19899_A1Down-0.4566694574
GSE19899_A2Up0.1898634724
PubMed_21979375_A1Down-0.5150195293
PubMed_21979375_A2Down-0.2881435092
GSE35957Up0.1767167348
GSE36640Up0.7056890432
GSE54402Down-0.3612692200
GSE9593Up0.4428627180
GSE43922Down-0.0080983063
GSE24585Up1.0155865802
GSE37065Up0.1723062205
GSE28863_A1Up0.2900431477
GSE28863_A2Up0.5882060718
GSE28863_A3Down-0.3213648641
GSE28863_A4Down-0.2367788615
GSE48662Up0.4132185982

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT005906qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-155-5pMIMAT0000646MIRT020649ProteomicsFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028523ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1229-3pMIMAT0005584MIRT036312CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038178CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040760CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046717CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.