HCSGD entry for DAG1

1. General information

Official gene symbolDAG1
Entrez ID1605
Gene full namedystroglycan 1 (dystrophin-associated glycoprotein 1)
Other gene symbols156DAG A3a AGRNR DAG MDDGC7 MDDGC9
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIEAmolecular_function
GO:0002011Morphogenesis of an epithelial sheetIEAbiological_process
GO:0002162Dystroglycan bindingIEAmolecular_function
GO:0003779Actin bindingIDAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005604Basement membraneIDA IEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005654NucleoplasmIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005856CytoskeletonIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005913Cell-cell adherens junctionIEAcellular_component
GO:0005925Focal adhesionIDA IEAcellular_component
GO:0006509Membrane protein ectodomain proteolysisIDAbiological_process
GO:0006607NLS-bearing protein import into nucleusIDAbiological_process
GO:0007016Cytoskeletal anchoring at plasma membraneIEA IMPbiological_process
GO:0008307Structural constituent of muscleIMPmolecular_function
GO:0009279Cell outer membraneIEAcellular_component
GO:0015631Tubulin bindingIDAmolecular_function
GO:0016010Dystrophin-associated glycoprotein complexIDAcellular_component
GO:0016011Dystroglycan complexIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016340Calcium-dependent cell-matrix adhesionIEAbiological_process
GO:0017166Vinculin bindingIPImolecular_function
GO:0019048Modulation by virus of host morphology or physiologyIDAbiological_process
GO:0021682Nerve maturationIEAbiological_process
GO:0022011Myelination in peripheral nervous systemIEAbiological_process
GO:0030027LamellipodiumIDAcellular_component
GO:0030175FilopodiumIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033268Node of RanvierIEAcellular_component
GO:0034453Microtubule anchoringIMPbiological_process
GO:0042169SH2 domain bindingIDAmolecular_function
GO:0042383SarcolemmaIEAcellular_component
GO:0043034CostamereIEAcellular_component
GO:0043237Laminin-1 bindingISSmolecular_function
GO:0043409Negative regulation of MAPK cascadeIMPbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045121Membrane raftIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0051393Alpha-actinin bindingIDAmolecular_function
GO:0051898Negative regulation of protein kinase B signalingIMPbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEAbiological_process
GO:0060445Branching involved in salivary gland morphogenesisIEAbiological_process
GO:0070938Contractile ringIDAcellular_component
GO:0071679Commissural neuron axon guidanceIEAbiological_process
GO:0071711Basement membrane organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06331453210.29979826370.54299638671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1852536690
GSE13712_SHEARDown-0.2235883779
GSE13712_STATICDown-0.1841555819
GSE19018Up0.7945254538
GSE19899_A1Down-0.4566694574
GSE19899_A2Up0.1898634724
PubMed_21979375_A1Down-0.5150195293
PubMed_21979375_A2Down-0.2881435092
GSE35957Up0.1767167348
GSE36640Up0.7056890432
GSE54402Down-0.3612692200
GSE9593Up0.4428627180
GSE43922Down-0.0080983063
GSE24585Up1.0155865802
GSE37065Up0.1723062205
GSE28863_A1Up0.2900431477
GSE28863_A2Up0.5882060718
GSE28863_A3Down-0.3213648641
GSE28863_A4Down-0.2367788615
GSE48662Up0.4132185982

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29a-3pMIMAT0000086MIRT005906qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-155-5pMIMAT0000646MIRT020649ProteomicsFunctional MTI (Weak)18668040
hsa-miR-30a-5pMIMAT0000087MIRT028523ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1229-3pMIMAT0005584MIRT036312CLASHFunctional MTI (Weak)23622248
hsa-miR-423-5pMIMAT0004748MIRT038178CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-3pMIMAT0002891MIRT040760CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046717CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.