HCSGD entry for CYP11B2

1. General information

Official gene symbolCYP11B2
Entrez ID1585
Gene full namecytochrome P450, family 11, subfamily B, polypeptide 2
Other gene symbolsALDOS CPN2 CYP11B CYP11BL CYPXIB2 P-450C18 P450C18 P450aldo
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002017Regulation of blood volume by renal aldosteroneIMPbiological_process
GO:0003091Renal water homeostasisICbiological_process
GO:0004507Steroid 11-beta-monooxygenase activityIDAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005743Mitochondrial inner membraneIC TAScellular_component
GO:0006700C21-steroid hormone biosynthetic processIDAbiological_process
GO:0006705Mineralocorticoid biosynthetic processTASbiological_process
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0016125Sterol metabolic processTASbiological_process
GO:0020037Heme bindingIC IDAmolecular_function
GO:0032342Aldosterone biosynthetic processIDA IMPbiological_process
GO:0032870Cellular response to hormone stimulusIEPbiological_process
GO:0034651Cortisol biosynthetic processIMPbiological_process
GO:0035865Cellular response to potassium ionIEPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047783Corticosterone 18-monooxygenase activityIEAmolecular_function
GO:0055075Potassium ion homeostasisIMPbiological_process
GO:0055078Sodium ion homeostasisIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66501900380.74884642300.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0118790013
GSE13712_SHEARUp0.0430695383
GSE13712_STATICUp0.0368923090
GSE19018Up0.0396290028
GSE19899_A1Down-0.1607618786
GSE19899_A2Up0.3554649554
PubMed_21979375_A1Up0.1394868441
PubMed_21979375_A2Down-0.2532073877
GSE35957Down-0.1758373690
GSE36640Down-0.0377357041
GSE54402Down-0.0717829633
GSE9593Up0.0434598054
GSE43922Down-0.0130249006
GSE24585Up0.1171904387
GSE37065Down-0.0137958644
GSE28863_A1Down-0.0583099487
GSE28863_A2Up0.0243877882
GSE28863_A3Up0.4135851575
GSE28863_A4Up0.0841287808
GSE48662Up0.0068280567

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SpironolactoneDB00421 APRD01234

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029873MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.