HCSGD entry for CYP11B2
1. General information
| Official gene symbol | CYP11B2 |
|---|---|
| Entrez ID | 1585 |
| Gene full name | cytochrome P450, family 11, subfamily B, polypeptide 2 |
| Other gene symbols | ALDOS CPN2 CYP11B CYP11BL CYPXIB2 P-450C18 P450C18 P450aldo |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002017 | Regulation of blood volume by renal aldosterone | IMP | biological_process |
| GO:0003091 | Renal water homeostasis | IC | biological_process |
| GO:0004507 | Steroid 11-beta-monooxygenase activity | IDA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IC TAS | cellular_component |
| GO:0006700 | C21-steroid hormone biosynthetic process | IDA | biological_process |
| GO:0006705 | Mineralocorticoid biosynthetic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0020037 | Heme binding | IC IDA | molecular_function |
| GO:0032342 | Aldosterone biosynthetic process | IDA IMP | biological_process |
| GO:0032870 | Cellular response to hormone stimulus | IEP | biological_process |
| GO:0034651 | Cortisol biosynthetic process | IMP | biological_process |
| GO:0035865 | Cellular response to potassium ion | IEP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0047783 | Corticosterone 18-monooxygenase activity | IEA | molecular_function |
| GO:0055075 | Potassium ion homeostasis | IMP | biological_process |
| GO:0055078 | Sodium ion homeostasis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6650190038 | 0.7488464230 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0118790013 |
| GSE13712_SHEAR | Up | 0.0430695383 |
| GSE13712_STATIC | Up | 0.0368923090 |
| GSE19018 | Up | 0.0396290028 |
| GSE19899_A1 | Down | -0.1607618786 |
| GSE19899_A2 | Up | 0.3554649554 |
| PubMed_21979375_A1 | Up | 0.1394868441 |
| PubMed_21979375_A2 | Down | -0.2532073877 |
| GSE35957 | Down | -0.1758373690 |
| GSE36640 | Down | -0.0377357041 |
| GSE54402 | Down | -0.0717829633 |
| GSE9593 | Up | 0.0434598054 |
| GSE43922 | Down | -0.0130249006 |
| GSE24585 | Up | 0.1171904387 |
| GSE37065 | Down | -0.0137958644 |
| GSE28863_A1 | Down | -0.0583099487 |
| GSE28863_A2 | Up | 0.0243877882 |
| GSE28863_A3 | Up | 0.4135851575 |
| GSE28863_A4 | Up | 0.0841287808 |
| GSE48662 | Up | 0.0068280567 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Spironolactone | DB00421 | APRD01234 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029873 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
