HCSGD entry for CYP2D6

1. General information

Official gene symbolCYP2D6
Entrez ID1565
Gene full namecytochrome P450, family 2, subfamily D, polypeptide 6
Other gene symbolsCPD6 CYP2D CYP2D7AP CYP2D7BP CYP2D7P2 CYP2D8P2 CYP2DL1 CYPIID6 P450-DB1 P450C2D P450DB1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004497Monooxygenase activityIDAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005739MitochondrionIDAcellular_component
GO:0005783Endoplasmic reticulumTAScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0006805Xenobiotic metabolic processTASbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008202Steroid metabolic processIMPbiological_process
GO:0009804Coumarin metabolic processIDAbiological_process
GO:0009820Alkaloid metabolic processIDAbiological_process
GO:0009822Alkaloid catabolic processIDAbiological_process
GO:0016098Monoterpenoid metabolic processIDAbiological_process
GO:0016491Oxidoreductase activityIDAmolecular_function
GO:0016712Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0017144Drug metabolic processIDA IMPbiological_process
GO:0020037Heme bindingIDA IEAmolecular_function
GO:0033076Isoquinoline alkaloid metabolic processIDAbiological_process
GO:0042737Drug catabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046483Heterocycle metabolic processIDAbiological_process
GO:0051100Negative regulation of bindingIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0070330Aromatase activityIEAmolecular_function
GO:0070989Oxidative demethylationIDAbiological_process
GO:0090350Negative regulation of cellular organofluorine metabolic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30781334300.94884133200.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1114706057
GSE13712_SHEARDown-0.0038179738
GSE13712_STATICUp0.1510399408
GSE19018Up0.0841450228
GSE19899_A1Up0.0464126189
GSE19899_A2Up0.0785400611
PubMed_21979375_A1Up0.1452857521
PubMed_21979375_A2Up0.0164329012
GSE35957Up0.3969961498
GSE36640Up0.2274250903
GSE54402Up0.0376162347
GSE9593Up0.2168688322
GSE43922Up0.0548335259
GSE24585Down-0.0384447106
GSE37065Down-0.0232875188
GSE28863_A1Down-0.0561572842
GSE28863_A2Up0.0655618334
GSE28863_A3Up0.3305273185
GSE28863_A4Up0.1144982046
GSE48662Down-0.0023431734

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PaliperidoneDB01267 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029578MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.