HCSGD entry for CYBA

1. General information

Official gene symbolCYBA
Entrez ID1535
Gene full namecytochrome b-245, alpha polypeptide
Other gene symbolsp22-PHOX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0003106Negative regulation of glomerular filtration by angiotensinIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0006801Superoxide metabolic processIMPbiological_process
GO:0006954Inflammatory responseIMPbiological_process
GO:0009055Electron carrier activityIDA TASmolecular_function
GO:0014895Smooth muscle hypertrophyISSbiological_process
GO:0016175Superoxide-generating NADPH oxidase activityIMPmolecular_function
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017004Cytochrome complex assemblyIDAbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0030141Secretory granuleTAScellular_component
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042554Superoxide anion generationIMPbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043020NADPH oxidase complexIDA IMPcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045087Innate immune responseIMPbiological_process
GO:0045730Respiratory burstIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050665Hydrogen peroxide biosynthetic processISSbiological_process
GO:0051701Interaction with hostTASbiological_process
GO:0055114Oxidation-reduction processIMPbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071480Cellular response to gamma radiationIEAbiological_process
GO:0090382Phagosome maturationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13918537290.44890894720.75056304041.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1287353830
GSE13712_SHEARDown-0.9149853331
GSE13712_STATICDown-0.7754778490
GSE19018Up0.0180589434
GSE19899_A1Up0.1790377510
GSE19899_A2Up0.9423590522
PubMed_21979375_A1Up0.3645431271
PubMed_21979375_A2Up0.3609859510
GSE35957Up0.1705329683
GSE36640Up0.2813565561
GSE54402Up0.3085584446
GSE9593Up0.2116540173
GSE43922Up0.1238071785
GSE24585Down-0.4774140206
GSE37065Down-0.1085048859
GSE28863_A1Down-0.1916142583
GSE28863_A2Down-0.2548105452
GSE28863_A3Up0.1812307193
GSE28863_A4Up0.1334139946
GSE48662Up0.4762219509

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DextromethorphanDB00514 APRD00655

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT044553CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046446CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25879533Intermittent but not constant high glucose strikingly up-regulated the expression of p22phox, an NADPH oxidase component, increasing superoxide
25879533The small interfering RNA of p22phox undermined the increase in SA-beta-gal activity induced by intermittent high glucose
18779176Three siRNAs targeting p22phox were designed and synthesized in vitro, which were used to transfect ECV-304 cultured in vitro for selecting the most powerful and most suitable transfection concentration and time
18779176RT-PCR and Western blot were used to analyze mRNA and protein expression of NAD(P)H oxidase subunit p22phox
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