HCSGD entry for CYBA

1. General information

Official gene symbolCYBA
Entrez ID1535
Gene full namecytochrome b-245, alpha polypeptide
Other gene symbolsp22-PHOX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001938Positive regulation of endothelial cell proliferationIEAbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0003106Negative regulation of glomerular filtration by angiotensinIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0006801Superoxide metabolic processIMPbiological_process
GO:0006954Inflammatory responseIMPbiological_process
GO:0009055Electron carrier activityIDA TASmolecular_function
GO:0014895Smooth muscle hypertrophyISSbiological_process
GO:0016175Superoxide-generating NADPH oxidase activityIMPmolecular_function
GO:0016324Apical plasma membraneIEAcellular_component
GO:0017004Cytochrome complex assemblyIDAbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0020037Heme bindingIEAmolecular_function
GO:0030141Secretory granuleTAScellular_component
GO:0030307Positive regulation of cell growthIEAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030670Phagocytic vesicle membraneTAScellular_component
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042554Superoxide anion generationIMPbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043020NADPH oxidase complexIDA IMPcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0045087Innate immune responseIMPbiological_process
GO:0045730Respiratory burstIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0050665Hydrogen peroxide biosynthetic processISSbiological_process
GO:0051701Interaction with hostTASbiological_process
GO:0055114Oxidation-reduction processIMPbiological_process
GO:0070555Response to interleukin-1IEAbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
GO:0071356Cellular response to tumor necrosis factorIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0071480Cellular response to gamma radiationIEAbiological_process
GO:0090382Phagosome maturationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13918537290.44890894720.75056304041.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1287353830
GSE13712_SHEARDown-0.9149853331
GSE13712_STATICDown-0.7754778490
GSE19018Up0.0180589434
GSE19899_A1Up0.1790377510
GSE19899_A2Up0.9423590522
PubMed_21979375_A1Up0.3645431271
PubMed_21979375_A2Up0.3609859510
GSE35957Up0.1705329683
GSE36640Up0.2813565561
GSE54402Up0.3085584446
GSE9593Up0.2116540173
GSE43922Up0.1238071785
GSE24585Down-0.4774140206
GSE37065Down-0.1085048859
GSE28863_A1Down-0.1916142583
GSE28863_A2Down-0.2548105452
GSE28863_A3Up0.1812307193
GSE28863_A4Up0.1334139946
GSE48662Up0.4762219509

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DextromethorphanDB00514 APRD00655

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT044553CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046446CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25879533Intermittent but not constant high glucose strikingly up-regulated the expression of p22phox, an NADPH oxidase component, increasing superoxide
25879533The small interfering RNA of p22phox undermined the increase in SA-beta-gal activity induced by intermittent high glucose
18779176Three siRNAs targeting p22phox were designed and synthesized in vitro, which were used to transfect ECV-304 cultured in vitro for selecting the most powerful and most suitable transfection concentration and time
18779176RT-PCR and Western blot were used to analyze mRNA and protein expression of NAD(P)H oxidase subunit p22phox
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