HCSGD entry for CTSS

1. General information

Official gene symbolCTSS
Entrez ID1520
Gene full namecathepsin S
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002250Adaptive immune responseIEPbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002480Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTASbiological_process
GO:0004197Cysteine-type endopeptidase activityTASmolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005764LysosomeIDAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008234Cysteine-type peptidase activityIEAmolecular_function
GO:0019882Antigen processing and presentationTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0036021Endolysosome lumenTAScellular_component
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0097067Cellular response to thyroid hormone stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00001892410.84680193760.01465000001.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.6679292426
GSE13712_SHEARUp0.3313142876
GSE13712_STATICDown-0.0294628811
GSE19018Down-0.0703455356
GSE19899_A1Up2.2555024845
GSE19899_A2Up6.3159378151
PubMed_21979375_A1Up4.6705636674
PubMed_21979375_A2Up5.7579721966
GSE35957Down-1.2581688350
GSE36640Up0.3095062491
GSE54402Up3.4297573396
GSE9593Down-0.3216074430
GSE43922Up3.3768591979
GSE24585Up0.0504488026
GSE37065Up1.5965349378
GSE28863_A1Down-0.1547483505
GSE28863_A2Up2.7684466866
GSE28863_A3Down-0.1599966225
GSE28863_A4Down-0.0304593259
GSE48662Down-0.0185286968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]AmideDB03767 EXPT00719
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-AmideDB03837 EXPT00801
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-AmideDB03984 EXPT00813
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDEDB07520 -
N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDEDB07587 -
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDEDB07589 -
N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDEDB07839 -
N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDEDB07878 -
(1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATEDB08195 -
2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOLDB08611 -
N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamideDB08752 -
N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamideDB08755 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.