HCSGD entry for CTSS

1. General information

Official gene symbolCTSS
Entrez ID1520
Gene full namecathepsin S
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002250Adaptive immune responseIEPbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002480Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTASbiological_process
GO:0004197Cysteine-type endopeptidase activityTASmolecular_function
GO:0005576Extracellular regionNAScellular_component
GO:0005764LysosomeIDAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008234Cysteine-type peptidase activityIEAmolecular_function
GO:0019882Antigen processing and presentationTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0036021Endolysosome lumenTAScellular_component
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043231Intracellular membrane-bounded organelleIDAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0097067Cellular response to thyroid hormone stimulusIEPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00001892410.84680193760.01465000001.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up2.6679292426
GSE13712_SHEARUp0.3313142876
GSE13712_STATICDown-0.0294628811
GSE19018Down-0.0703455356
GSE19899_A1Up2.2555024845
GSE19899_A2Up6.3159378151
PubMed_21979375_A1Up4.6705636674
PubMed_21979375_A2Up5.7579721966
GSE35957Down-1.2581688350
GSE36640Up0.3095062491
GSE54402Up3.4297573396
GSE9593Down-0.3216074430
GSE43922Up3.3768591979
GSE24585Up0.0504488026
GSE37065Up1.5965349378
GSE28863_A1Down-0.1547483505
GSE28863_A2Up2.7684466866
GSE28863_A3Down-0.1599966225
GSE28863_A4Down-0.0304593259
GSE48662Down-0.0185286968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Morpholine-4-Carboxylic Acid [1s-(2-Benzyloxy-1r-Cyano-Ethylcarbamoyl)-3-Methyl-Butyl]AmideDB03767 EXPT00719
Morpholine-4-Carboxylic Acid (1-(3-Benzenesulfonyl-1-Phenethylallylcarbamoyl)-3-Methylbutyl)-AmideDB03837 EXPT00801
Morpholine-4-Carboxylic Acid [1-(2-Benzylsulfanyl-1-Formyl-Ethylcarbamoyl)-2-Phenyl-Ethyl]-AmideDB03984 EXPT00813
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(MORPHOLIN-4-YLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDEDB07520 -
N-(1-CYANOCYCLOPROPYL)-3-({[(2S)-5-OXOPYRROLIDIN-2-YL]METHYL}SULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-FLUOROPHENYL)ETHYL]-L-ALANINAMIDEDB07587 -
N-[1-(AMINOMETHYL)CYCLOPROPYL]-3-(BENZYLSULFONYL)-N~2~-[(1S)-2,2,2-TRIFLUORO-1-(4-HYDROXYPHENYL)ETHYL]-L-ALANINAMIDEDB07589 -
N~2~-1,3-BENZOXAZOL-2-YL-3-CYCLOHEXYL-N-{2-[(4-METHOXYPHENYL)AMINO]ETHYL}-L-ALANINAMIDEDB07839 -
N-[(1S)-1-{1-[(1R,3E)-1-ACETYLPENT-3-EN-1-YL]-1H-1,2,3-TRIAZOL-4-YL}-1,2-DIMETHYLPROPYL]BENZAMIDEDB07878 -
(1R)-2-[(CYANOMETHYL)AMINO]-1-({[2-(DIFLUOROMETHOXY)BENZYL]SULFONYL}METHYL)-2-OXOETHYL MORPHOLINE-4-CARBOXYLATEDB08195 -
2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOLDB08611 -
N-[(1S)-2-[(4-cyano-1-methylpiperidin-4-yl)amino]-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamideDB08752 -
N-[(1S)-2-{[(1R)-2-(benzyloxy)-1-cyano-1-methylethyl]amino}-1-(cyclohexylmethyl)-2-oxoethyl]morpholine-4-carboxamideDB08755 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.