HCSGD entry for CTSG
1. General information
| Official gene symbol | CTSG |
|---|---|
| Entrez ID | 1511 |
| Gene full name | cathepsin G |
| Other gene symbols | CATG CG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002003 | Angiotensin maturation | TAS | biological_process |
| GO:0004252 | Serine-type endopeptidase activity | IDA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0006508 | Proteolysis | IDA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0008201 | Heparin binding | IDA | molecular_function |
| GO:0008233 | Peptidase activity | IDA | molecular_function |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030141 | Secretory granule | IDA | cellular_component |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0044130 | Negative regulation of growth of symbiont in host | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0050778 | Positive regulation of immune response | IEA | biological_process |
| GO:0050832 | Defense response to fungus | IEA | biological_process |
| GO:0070946 | Neutrophil mediated killing of gram-positive bacterium | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5908728848 | 0.6099457505 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0411707918 |
| GSE13712_SHEAR | Down | -0.1298161058 |
| GSE13712_STATIC | Down | -0.0198083814 |
| GSE19018 | Up | 0.2572704683 |
| GSE19899_A1 | Up | 0.0767608386 |
| GSE19899_A2 | Up | 0.1948540917 |
| PubMed_21979375_A1 | Down | -0.2515056926 |
| PubMed_21979375_A2 | Down | -0.0671682146 |
| GSE35957 | Up | 0.3666846122 |
| GSE36640 | Down | -0.0880249930 |
| GSE54402 | Up | 0.0024708371 |
| GSE9593 | Down | -0.0116854233 |
| GSE43922 | Up | 0.0102996068 |
| GSE24585 | Down | -0.1552855086 |
| GSE37065 | Down | -0.0812565673 |
| GSE28863_A1 | Down | -0.1760662348 |
| GSE28863_A2 | Down | -0.0938233581 |
| GSE28863_A3 | Up | 0.3987680254 |
| GSE28863_A4 | Up | 0.0138808085 |
| GSE48662 | Up | 0.1063663974 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Bis-Napthyl Beta-Ketophosphonic Acid | DB02360 | EXPT01984 |
| 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid | DB04016 | EXPT02424 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22506108 | We demonstrate the role of neutrophilic cathepsin G, detected as an immunogen on erythrocyte membrane, in band 3 cleavage |
| 22506108 | Cathepsin G from serum adsorbs to the erythrocyte membrane to mediate cleavage of band 3 and therefore contribute to the eryptotic phenotype in CML |
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