HCSGD entry for CTSG

1. General information

Official gene symbolCTSG
Entrez ID1511
Gene full namecathepsin G
Other gene symbolsCATG CG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002003Angiotensin maturationTASbiological_process
GO:0004252Serine-type endopeptidase activityIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006508ProteolysisIDAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008233Peptidase activityIDAmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030141Secretory granuleIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0044130Negative regulation of growth of symbiont in hostIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050778Positive regulation of immune responseIEAbiological_process
GO:0050832Defense response to fungusIEAbiological_process
GO:0070946Neutrophil mediated killing of gram-positive bacteriumIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.59087288480.60994575050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0411707918
GSE13712_SHEARDown-0.1298161058
GSE13712_STATICDown-0.0198083814
GSE19018Up0.2572704683
GSE19899_A1Up0.0767608386
GSE19899_A2Up0.1948540917
PubMed_21979375_A1Down-0.2515056926
PubMed_21979375_A2Down-0.0671682146
GSE35957Up0.3666846122
GSE36640Down-0.0880249930
GSE54402Up0.0024708371
GSE9593Down-0.0116854233
GSE43922Up0.0102996068
GSE24585Down-0.1552855086
GSE37065Down-0.0812565673
GSE28863_A1Down-0.1760662348
GSE28863_A2Down-0.0938233581
GSE28863_A3Up0.3987680254
GSE28863_A4Up0.0138808085
GSE48662Up0.1063663974

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Bis-Napthyl Beta-Ketophosphonic AcidDB02360 EXPT01984
2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic AcidDB04016 EXPT02424

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22506108We demonstrate the role of neutrophilic cathepsin G, detected as an immunogen on erythrocyte membrane, in band 3 cleavage
22506108Cathepsin G from serum adsorbs to the erythrocyte membrane to mediate cleavage of band 3 and therefore contribute to the eryptotic phenotype in CML
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