HCSGD entry for CRYAB

1. General information

Official gene symbolCRYAB
Entrez ID1410
Gene full namecrystallin, alpha B
Other gene symbolsCMD1II CRYA2 CTPP2 HSPB5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0002088Lens development in camera-type eyeIEAbiological_process
GO:0005212Structural constituent of eye lensIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006457Protein foldingIEAbiological_process
GO:0006936Muscle contractionTASbiological_process
GO:0007021Tubulin complex assemblyIEAbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010941Regulation of cell deathIMPbiological_process
GO:0015630Microtubule cytoskeletonIEAcellular_component
GO:0030018Z discIEAcellular_component
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0031109Microtubule polymerization or depolymerizationIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032387Negative regulation of intracellular transportIDAbiological_process
GO:0032432Actin filament bundleIEAcellular_component
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043066Negative regulation of apoptotic processIDA IEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051082Unfolded protein bindingIPImolecular_function
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051403Stress-activated MAPK cascadeIEAbiological_process
GO:0060561Apoptotic process involved in morphogenesisIEAbiological_process
GO:0071480Cellular response to gamma radiationIMPbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04336366020.00529655410.46340840440.1480695329

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8022686515
GSE13712_SHEARUp0.9926929399
GSE13712_STATICDown-0.1217327676
GSE19018Up0.6153255238
GSE19899_A1Down-1.2914658394
GSE19899_A2Down-2.0056711524
PubMed_21979375_A1Down-4.9897349316
PubMed_21979375_A2Down-4.2144709408
GSE35957Up0.3296932392
GSE36640Up1.0611293072
GSE54402Down-1.3643860621
GSE9593Down-0.0307453235
GSE43922Down-3.1365958273
GSE24585Up0.2603837508
GSE37065Up1.1143666599
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.3705484128

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.