HCSGD entry for CRYAB

1. General information

Official gene symbolCRYAB
Entrez ID1410
Gene full namecrystallin, alpha B
Other gene symbolsCMD1II CRYA2 CTPP2 HSPB5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0002088Lens development in camera-type eyeIEAbiological_process
GO:0005212Structural constituent of eye lensIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006457Protein foldingIEAbiological_process
GO:0006936Muscle contractionTASbiological_process
GO:0007021Tubulin complex assemblyIEAbiological_process
GO:0007517Muscle organ developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0010629Negative regulation of gene expressionIEAbiological_process
GO:0010941Regulation of cell deathIMPbiological_process
GO:0015630Microtubule cytoskeletonIEAcellular_component
GO:0030018Z discIEAcellular_component
GO:0030308Negative regulation of cell growthIEAbiological_process
GO:0031109Microtubule polymerization or depolymerizationIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032387Negative regulation of intracellular transportIDAbiological_process
GO:0032432Actin filament bundleIEAcellular_component
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043066Negative regulation of apoptotic processIDA IEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0051082Unfolded protein bindingIPImolecular_function
GO:0051260Protein homooligomerizationIDAbiological_process
GO:0051403Stress-activated MAPK cascadeIEAbiological_process
GO:0060561Apoptotic process involved in morphogenesisIEAbiological_process
GO:0071480Cellular response to gamma radiationIMPbiological_process
GO:2000378Negative regulation of reactive oxygen species metabolic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04336366020.00529655410.46340840440.1480695329

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8022686515
GSE13712_SHEARUp0.9926929399
GSE13712_STATICDown-0.1217327676
GSE19018Up0.6153255238
GSE19899_A1Down-1.2914658394
GSE19899_A2Down-2.0056711524
PubMed_21979375_A1Down-4.9897349316
PubMed_21979375_A2Down-4.2144709408
GSE35957Up0.3296932392
GSE36640Up1.0611293072
GSE54402Down-1.3643860621
GSE9593Down-0.0307453235
GSE43922Down-3.1365958273
GSE24585Up0.2603837508
GSE37065Up1.1143666599
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.3705484128

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.