HCSGD entry for CRY1

1. General information

Official gene symbolCRY1
Entrez ID1407
Gene full namecryptochrome 1 (photolyase-like)
Other gene symbolsPHLL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000989Transcription factor binding transcription factor activityIDAmolecular_function
GO:0001047Core promoter bindingISSmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0003690Double-stranded DNA bindingIDA IEAmolecular_function
GO:0003904Deoxyribodipyrimidine photo-lyase activityIDAmolecular_function
GO:0003914DNA (6-4) photolyase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0009785Blue light signaling pathwayNASbiological_process
GO:0009882Blue light photoreceptor activityNASmolecular_function
GO:0018298Protein-chromophore linkageIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019902Phosphatase bindingIPImolecular_function
GO:0032922Circadian regulation of gene expressionISSbiological_process
GO:0042752Regulation of circadian rhythmIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38767552900.05072267010.99999024730.4226246914

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3586094286
GSE13712_SHEARDown-0.1162576663
GSE13712_STATICUp0.0614873400
GSE19018Down-0.5036046519
GSE19899_A1Up0.0136042927
GSE19899_A2Up0.0240734494
PubMed_21979375_A1Up0.7304770931
PubMed_21979375_A2Down-0.5992476801
GSE35957Down-0.3241328083
GSE36640Down-0.5667793060
GSE54402Up0.7557042795
GSE9593Down-0.5189648549
GSE43922Down-0.0314641457
GSE24585Up0.4267558879
GSE37065Down-0.0350655931
GSE28863_A1Up0.1732324010
GSE28863_A2Up0.2764081329
GSE28863_A3Down-0.9662866173
GSE28863_A4Up0.2146446573
GSE48662Down-0.4398752225

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-324-5pMIMAT0000761MIRT043195CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26961881Mouse embryonic fibroblasts prepared from animals deficient in negative circadian clock regulators, Period2 (Per2) or Cryptochrome1/2 (Cry1/2), were prone to transformation induced by co-expression of H-ras(V12) and SV40 large T antigen (SV40LT)
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