HCSGD entry for CRY1

1. General information

Official gene symbolCRY1
Entrez ID1407
Gene full namecryptochrome 1 (photolyase-like)
Other gene symbolsPHLL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000989Transcription factor binding transcription factor activityIDAmolecular_function
GO:0001047Core promoter bindingISSmolecular_function
GO:0003677DNA bindingTASmolecular_function
GO:0003690Double-stranded DNA bindingIDA IEAmolecular_function
GO:0003904Deoxyribodipyrimidine photo-lyase activityIDAmolecular_function
GO:0003914DNA (6-4) photolyase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0007623Circadian rhythmIEAbiological_process
GO:0009785Blue light signaling pathwayNASbiological_process
GO:0009882Blue light photoreceptor activityNASmolecular_function
GO:0018298Protein-chromophore linkageIEAbiological_process
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0019902Phosphatase bindingIPImolecular_function
GO:0032922Circadian regulation of gene expressionISSbiological_process
GO:0042752Regulation of circadian rhythmIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38767552900.05072267010.99999024730.4226246914

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3586094286
GSE13712_SHEARDown-0.1162576663
GSE13712_STATICUp0.0614873400
GSE19018Down-0.5036046519
GSE19899_A1Up0.0136042927
GSE19899_A2Up0.0240734494
PubMed_21979375_A1Up0.7304770931
PubMed_21979375_A2Down-0.5992476801
GSE35957Down-0.3241328083
GSE36640Down-0.5667793060
GSE54402Up0.7557042795
GSE9593Down-0.5189648549
GSE43922Down-0.0314641457
GSE24585Up0.4267558879
GSE37065Down-0.0350655931
GSE28863_A1Up0.1732324010
GSE28863_A2Up0.2764081329
GSE28863_A3Down-0.9662866173
GSE28863_A4Up0.2146446573
GSE48662Down-0.4398752225

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-324-5pMIMAT0000761MIRT043195CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26961881Mouse embryonic fibroblasts prepared from animals deficient in negative circadian clock regulators, Period2 (Per2) or Cryptochrome1/2 (Cry1/2), were prone to transformation induced by co-expression of H-ras(V12) and SV40 large T antigen (SV40LT)
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