HCSGD entry for COL1A1

1. General information

Official gene symbolCOL1A1
Entrez ID1277
Gene full namecollagen, type I, alpha 1
Other gene symbolsOI4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIMPbiological_process
GO:0001568Blood vessel developmentIMPbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001957Intramembranous ossificationIEAbiological_process
GO:0001958Endochondral ossificationIEAbiological_process
GO:0005201Extracellular matrix structural constituentIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005584Collagen type IIMPcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0007584Response to nutrientIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007601Visual perceptionIMPbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0010812Negative regulation of cell-substrate adhesionIEAbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIMPbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0031012Extracellular matrixIDA ISScellular_component
GO:0031960Response to corticosteroidIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032964Collagen biosynthetic processIMPbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0034505Tooth mineralizationIMPbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIDAmolecular_function
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043589Skin morphogenesisIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048407Platelet-derived growth factor bindingIDAmolecular_function
GO:0048706Embryonic skeletal system developmentIMPbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0060346Bone trabecula formationIEAbiological_process
GO:0060351Cartilage development involved in endochondral bone morphogenesisIEAbiological_process
GO:0070208Protein heterotrimerizationIEAbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20611688010.00525099730.87503264520.1475770544

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6179341878
GSE13712_SHEARUp0.0882016432
GSE13712_STATICUp0.0618651515
GSE19018Up0.1153131657
GSE19899_A1Down-0.8080071627
GSE19899_A2Down-1.6799811204
PubMed_21979375_A1Down-2.3817309037
PubMed_21979375_A2Down-1.4719773500
GSE35957Up0.1823105669
GSE36640Down-0.2030941480
GSE54402Down-1.2205435276
GSE9593Down-0.3628526832
GSE43922Down-1.2717556551
GSE24585Up0.6462836986
GSE37065Down-1.1942224029
GSE28863_A1Up1.3055550569
GSE28863_A2Up0.8246918320
GSE28863_A3Up0.5862316856
GSE28863_A4Down-0.0089001448
GSE48662Up0.0819825830

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Collagenase clostridium histolyticumDB00048 BTD00010 | BIOD00010
HalofuginoneDB04866 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29b-3pMIMAT0000100MIRT000100Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI19913496
hsa-miR-29b-3pMIMAT0000100MIRT000100Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20657750
hsa-miR-29b-3pMIMAT0000100MIRT000100Luciferase reporter assayFunctional MTI23478036
hsa-miR-29b-3pMIMAT0000100MIRT000100Reporter assayFunctional MTI21769867
hsa-miR-29c-3pMIMAT0000681MIRT000928Luciferase reporter assay//Reporter assay;OtherFunctional MTI18390668
hsa-miR-143-3pMIMAT0000435MIRT004242Immunoblot//Luciferase reporter assay//qRT-PCRNon-Functional MTI19913496
hsa-miR-133a-3pMIMAT0000427MIRT021714Reporter assayFunctional MTI21769867
hsa-miR-124-3pMIMAT0000422MIRT022587Proteomics;MicroarrayFunctional MTI (Weak)18668037
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-29c-3pMIMAT00006813hsa-miR-29c18390668
hsa-miR-29c-3pMIMAT00006811hsa-miR-29c18390668
hsa-miR-29c-3pMIMAT00006812hsa-miR-29c18390668
hsa-miR-218-5pMIMAT0000275NAhsa-miR-218{Western blot}{overexpression by miRNA precursor transfection}19913496
hsa-miR-29b-3pMIMAT0000100NAhsa-miR-29b{Western blot}{overexpression by miRNA precursor transfection}19913496
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26899446Subsequent cell cycle analysis was performed and expression level of COL1A1, elastin and MMP-1 were evaluated
26899446Additionally, transfection of miR-34b-5p mimics induced cell cycle arrest in HDFs, decreased the expression of both COL1A1 and elastin and increased MMP-1 expression
26899446MiR-34 in HDFs modulated the cell function and expression of MMP-1, COL1A1 and elastin
23106341There was a higher protein expression of Sox9, but a lower mRNA expression of Col1a1, Scx, and Tnmd in TDSCs (CI) in a basal medium
22673730NF-kappaB accumulation associated with COL1A1 transactivators defects during chronological aging represses type I collagen expression through a -112/-61-bp region of the COL1A1 promoter in human skin fibroblasts
22673730Here, we demonstrated that low levels of type I collagen detected in aged skin fibroblasts are attributable to an inhibition of COL1A1 transcription
22673730Indeed, on one hand, we observed decreased binding activities of specific proteins 1 and 3, CCAAT-binding factor, and human collagen-Kruppel box, which are well-known COL1A1 transactivators acting through the -112/-61-bp promoter sequence
22673730The forced expression of NF-kappaB performed in young fibroblasts was able to establish an old-like phenotype by repressing COL1A1 expression through the short -112/-61-bp COL1A1 promoter and by elevating the senescent cell distribution
22358238The expression levels of ELN, COL1A1, MMP1, CCND1, RB1, and IL6 genes were determined using the quantitative real-time polymerase chain reaction
12089561Here we have used AAV vectors to introduce large (>1 kb) functional transgene cassettes into the hypoxanthine phosphoribosyl transferase (HPRT) and Type I collagen (COL1A1) loci in normal human fibroblasts
Entries Per Page
Displaying Page of