HCSGD entry for COL1A1

1. General information

Official gene symbolCOL1A1
Entrez ID1277
Gene full namecollagen, type I, alpha 1
Other gene symbolsOI4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentIMPbiological_process
GO:0001568Blood vessel developmentIMPbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001957Intramembranous ossificationIEAbiological_process
GO:0001958Endochondral ossificationIEAbiological_process
GO:0005201Extracellular matrix structural constituentIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005584Collagen type IIMPcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0007584Response to nutrientIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007601Visual perceptionIMPbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0010718Positive regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0010812Negative regulation of cell-substrate adhesionIEAbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030199Collagen fibril organizationIMPbiological_process
GO:0030335Positive regulation of cell migrationIDAbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0031012Extracellular matrixIDA ISScellular_component
GO:0031960Response to corticosteroidIEAbiological_process
GO:0032355Response to estradiolIEAbiological_process
GO:0032964Collagen biosynthetic processIMPbiological_process
GO:0034504Protein localization to nucleusIDAbiological_process
GO:0034505Tooth mineralizationIMPbiological_process
GO:0042542Response to hydrogen peroxideIEAbiological_process
GO:0042802Identical protein bindingIDAmolecular_function
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0043589Skin morphogenesisIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048407Platelet-derived growth factor bindingIDAmolecular_function
GO:0048706Embryonic skeletal system developmentIMPbiological_process
GO:0050900Leukocyte migrationTASbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0060325Face morphogenesisIEAbiological_process
GO:0060346Bone trabecula formationIEAbiological_process
GO:0060351Cartilage development involved in endochondral bone morphogenesisIEAbiological_process
GO:0070208Protein heterotrimerizationIEAbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071560Cellular response to transforming growth factor beta stimulusIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20611688010.00525099730.87503264520.1475770544

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6179341878
GSE13712_SHEARUp0.0882016432
GSE13712_STATICUp0.0618651515
GSE19018Up0.1153131657
GSE19899_A1Down-0.8080071627
GSE19899_A2Down-1.6799811204
PubMed_21979375_A1Down-2.3817309037
PubMed_21979375_A2Down-1.4719773500
GSE35957Up0.1823105669
GSE36640Down-0.2030941480
GSE54402Down-1.2205435276
GSE9593Down-0.3628526832
GSE43922Down-1.2717556551
GSE24585Up0.6462836986
GSE37065Down-1.1942224029
GSE28863_A1Up1.3055550569
GSE28863_A2Up0.8246918320
GSE28863_A3Up0.5862316856
GSE28863_A4Down-0.0089001448
GSE48662Up0.0819825830

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Collagenase clostridium histolyticumDB00048 BTD00010 | BIOD00010
HalofuginoneDB04866 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-29b-3pMIMAT0000100MIRT000100Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI19913496
hsa-miR-29b-3pMIMAT0000100MIRT000100Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI20657750
hsa-miR-29b-3pMIMAT0000100MIRT000100Luciferase reporter assayFunctional MTI23478036
hsa-miR-29b-3pMIMAT0000100MIRT000100Reporter assayFunctional MTI21769867
hsa-miR-29c-3pMIMAT0000681MIRT000928Luciferase reporter assay//Reporter assay;OtherFunctional MTI18390668
hsa-miR-143-3pMIMAT0000435MIRT004242Immunoblot//Luciferase reporter assay//qRT-PCRNon-Functional MTI19913496
hsa-miR-133a-3pMIMAT0000427MIRT021714Reporter assayFunctional MTI21769867
hsa-miR-124-3pMIMAT0000422MIRT022587Proteomics;MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-29c-3pMIMAT00006813hsa-miR-29c18390668
hsa-miR-29c-3pMIMAT00006811hsa-miR-29c18390668
hsa-miR-29c-3pMIMAT00006812hsa-miR-29c18390668
hsa-miR-218-5pMIMAT0000275NAhsa-miR-218{Western blot}{overexpression by miRNA precursor transfection}19913496
hsa-miR-29b-3pMIMAT0000100NAhsa-miR-29b{Western blot}{overexpression by miRNA precursor transfection}19913496
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26899446Subsequent cell cycle analysis was performed and expression level of COL1A1, elastin and MMP-1 were evaluated
26899446Additionally, transfection of miR-34b-5p mimics induced cell cycle arrest in HDFs, decreased the expression of both COL1A1 and elastin and increased MMP-1 expression
26899446MiR-34 in HDFs modulated the cell function and expression of MMP-1, COL1A1 and elastin
23106341There was a higher protein expression of Sox9, but a lower mRNA expression of Col1a1, Scx, and Tnmd in TDSCs (CI) in a basal medium
22673730NF-kappaB accumulation associated with COL1A1 transactivators defects during chronological aging represses type I collagen expression through a -112/-61-bp region of the COL1A1 promoter in human skin fibroblasts
22673730Here, we demonstrated that low levels of type I collagen detected in aged skin fibroblasts are attributable to an inhibition of COL1A1 transcription
22673730Indeed, on one hand, we observed decreased binding activities of specific proteins 1 and 3, CCAAT-binding factor, and human collagen-Kruppel box, which are well-known COL1A1 transactivators acting through the -112/-61-bp promoter sequence
22673730The forced expression of NF-kappaB performed in young fibroblasts was able to establish an old-like phenotype by repressing COL1A1 expression through the short -112/-61-bp COL1A1 promoter and by elevating the senescent cell distribution
22358238The expression levels of ELN, COL1A1, MMP1, CCND1, RB1, and IL6 genes were determined using the quantitative real-time polymerase chain reaction
12089561Here we have used AAV vectors to introduce large (>1 kb) functional transgene cassettes into the hypoxanthine phosphoribosyl transferase (HPRT) and Type I collagen (COL1A1) loci in normal human fibroblasts
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