HCSGD entry for CCR7

1. General information

Official gene symbolCCR7
Entrez ID1236
Gene full namechemokine (C-C motif) receptor 7
Other gene symbolsBLR2 CD197 CDw197 CMKBR7 EBI1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001768Establishment of T cell polarityICbiological_process
GO:0001954Positive regulation of cell-matrix adhesionICbiological_process
GO:0002407Dendritic cell chemotaxisICbiological_process
GO:0002408Myeloid dendritic cell chemotaxisICbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationIEA ISSbiological_process
GO:0002885Positive regulation of hypersensitivityIEA ISSbiological_process
GO:0002922Positive regulation of humoral immune responseIEA ISSbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005622IntracellularIDA IEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006935ChemotaxisIEAbiological_process
GO:0006954Inflammatory responseIEA NASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016493C-C chemokine receptor activityIEA ISSmolecular_function
GO:0019221Cytokine-mediated signaling pathwayIDA ISSbiological_process
GO:0030838Positive regulation of actin filament polymerizationICbiological_process
GO:0031274Positive regulation of pseudopodium assemblyICbiological_process
GO:0031529Ruffle organizationICbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032649Regulation of interferon-gamma productionIEA ISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionIEA ISSbiological_process
GO:0032862Activation of Rho GTPase activityICbiological_process
GO:0034695Response to prostaglandin EICbiological_process
GO:0035757Chemokine (C-C motif) ligand 19 bindingIPImolecular_function
GO:0035758Chemokine (C-C motif) ligand 21 bindingIPImolecular_function
GO:0038115Chemokine (C-C motif) ligand 19 signaling pathwayIDAbiological_process
GO:0038116Chemokine (C-C motif) ligand 21 signaling pathwayIDAbiological_process
GO:0038117C-C motif chemokine 19 receptor activityIDAmolecular_function
GO:0038121C-C motif chemokine 21 receptor activityIDAmolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingICbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityICbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045785Positive regulation of cell adhesionICbiological_process
GO:0045860Positive regulation of protein kinase activityICbiological_process
GO:0046330Positive regulation of JNK cascadeICbiological_process
GO:0050706Regulation of interleukin-1 beta secretionIEA ISSbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0051209Release of sequestered calcium ion into cytosolICbiological_process
GO:0051491Positive regulation of filopodium assemblyICbiological_process
GO:0051897Positive regulation of protein kinase B signalingICbiological_process
GO:0070098Chemokine-mediated signaling pathwayIDA ISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeICbiological_process
GO:0071731Response to nitric oxideICbiological_process
GO:0072610Interleukin-12 secretionIEA ISSbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIDA IEAbiological_process
GO:0097022Lymphocyte migration into lymph nodeTASbiological_process
GO:0097029Mature dendritic cell differentiationIEA ISSbiological_process
GO:2000107Negative regulation of leukocyte apoptotic processICbiological_process
GO:2000147Positive regulation of cell motilityICbiological_process
GO:2000510Positive regulation of dendritic cell chemotaxisIEA ISSbiological_process
GO:2000522Positive regulation of immunological synapse formationIEA ISSbiological_process
GO:2000525Positive regulation of T cell costimulationIEA ISSbiological_process
GO:2000526Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formationIEA ISSbiological_process
GO:2000547Regulation of dendritic cell dendrite assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23952910980.37329817640.92540267141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0207524284
GSE13712_SHEARUp0.0846427087
GSE13712_STATICDown-0.2333290743
GSE19018Down-0.1133318782
GSE19899_A1Up0.3459336568
GSE19899_A2Up0.3545856277
PubMed_21979375_A1Up0.4394788719
PubMed_21979375_A2Up0.3549450084
GSE35957Up0.0995632749
GSE36640Up0.0514672443
GSE54402Down-0.1949109578
GSE9593Down-0.0989025672
GSE43922Up0.1635711533
GSE24585Down-0.2403540864
GSE37065Up0.1944222303
GSE28863_A1Down-0.5261941909
GSE28863_A2Down-0.4510937382
GSE28863_A3Up0.4817323859
GSE28863_A4Down-0.1045603620
GSE48662Up0.3769049586

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018216MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.