HCSGD entry for CCR7

1. General information

Official gene symbolCCR7
Entrez ID1236
Gene full namechemokine (C-C motif) receptor 7
Other gene symbolsBLR2 CD197 CDw197 CMKBR7 EBI1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001768Establishment of T cell polarityICbiological_process
GO:0001954Positive regulation of cell-matrix adhesionICbiological_process
GO:0002407Dendritic cell chemotaxisICbiological_process
GO:0002408Myeloid dendritic cell chemotaxisICbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationIEA ISSbiological_process
GO:0002885Positive regulation of hypersensitivityIEA ISSbiological_process
GO:0002922Positive regulation of humoral immune responseIEA ISSbiological_process
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005622IntracellularIDA IEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006935ChemotaxisIEAbiological_process
GO:0006954Inflammatory responseIEA NASbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016493C-C chemokine receptor activityIEA ISSmolecular_function
GO:0019221Cytokine-mediated signaling pathwayIDA ISSbiological_process
GO:0030838Positive regulation of actin filament polymerizationICbiological_process
GO:0031274Positive regulation of pseudopodium assemblyICbiological_process
GO:0031529Ruffle organizationICbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0032649Regulation of interferon-gamma productionIEA ISSbiological_process
GO:0032735Positive regulation of interleukin-12 productionIEA ISSbiological_process
GO:0032862Activation of Rho GTPase activityICbiological_process
GO:0034695Response to prostaglandin EICbiological_process
GO:0035757Chemokine (C-C motif) ligand 19 bindingIPImolecular_function
GO:0035758Chemokine (C-C motif) ligand 21 bindingIPImolecular_function
GO:0038115Chemokine (C-C motif) ligand 19 signaling pathwayIDAbiological_process
GO:0038116Chemokine (C-C motif) ligand 21 signaling pathwayIDAbiological_process
GO:0038117C-C motif chemokine 19 receptor activityIDAmolecular_function
GO:0038121C-C motif chemokine 21 receptor activityIDAmolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingICbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityICbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045785Positive regulation of cell adhesionICbiological_process
GO:0045860Positive regulation of protein kinase activityICbiological_process
GO:0046330Positive regulation of JNK cascadeICbiological_process
GO:0050706Regulation of interleukin-1 beta secretionIEA ISSbiological_process
GO:0050862Positive regulation of T cell receptor signaling pathwayIEAbiological_process
GO:0051209Release of sequestered calcium ion into cytosolICbiological_process
GO:0051491Positive regulation of filopodium assemblyICbiological_process
GO:0051897Positive regulation of protein kinase B signalingICbiological_process
GO:0070098Chemokine-mediated signaling pathwayIDA ISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeICbiological_process
GO:0071731Response to nitric oxideICbiological_process
GO:0072610Interleukin-12 secretionIEA ISSbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIDA IEAbiological_process
GO:0097022Lymphocyte migration into lymph nodeTASbiological_process
GO:0097029Mature dendritic cell differentiationIEA ISSbiological_process
GO:2000107Negative regulation of leukocyte apoptotic processICbiological_process
GO:2000147Positive regulation of cell motilityICbiological_process
GO:2000510Positive regulation of dendritic cell chemotaxisIEA ISSbiological_process
GO:2000522Positive regulation of immunological synapse formationIEA ISSbiological_process
GO:2000525Positive regulation of T cell costimulationIEA ISSbiological_process
GO:2000526Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formationIEA ISSbiological_process
GO:2000547Regulation of dendritic cell dendrite assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.23952910980.37329817640.92540267141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0207524284
GSE13712_SHEARUp0.0846427087
GSE13712_STATICDown-0.2333290743
GSE19018Down-0.1133318782
GSE19899_A1Up0.3459336568
GSE19899_A2Up0.3545856277
PubMed_21979375_A1Up0.4394788719
PubMed_21979375_A2Up0.3549450084
GSE35957Up0.0995632749
GSE36640Up0.0514672443
GSE54402Down-0.1949109578
GSE9593Down-0.0989025672
GSE43922Up0.1635711533
GSE24585Down-0.2403540864
GSE37065Up0.1944222303
GSE28863_A1Down-0.5261941909
GSE28863_A2Down-0.4510937382
GSE28863_A3Up0.4817323859
GSE28863_A4Down-0.1045603620
GSE48662Up0.3769049586

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018216MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.