HCSGD entry for LEO1

1. General information

Official gene symbolLEO1
Entrez ID123169
Gene full nameLeo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other gene symbolsRDL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001711Endodermal cell fate commitmentISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006378MRNA polyadenylationIMPbiological_process
GO:0010390Histone monoubiquitinationIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016593Cdc73/Paf1 complexIDAcellular_component
GO:0019827Stem cell maintenanceIDAbiological_process
GO:0031442Positive regulation of mRNA 3'-end processingIMPbiological_process
GO:0032968Positive regulation of transcription elongation from RNA polymerase II promoterIDAbiological_process
GO:0033523Histone H2B ubiquitinationIDAbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03735821210.92781383310.43640155141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3323352011
GSE13712_SHEARUp0.1586332620
GSE13712_STATICUp0.0028864493
GSE19018Down-0.3353891848
GSE19899_A1Up0.1534689918
GSE19899_A2Up0.4833968948
PubMed_21979375_A1Up1.3621367020
PubMed_21979375_A2Up0.2438797489
GSE35957Down-0.2074089765
GSE36640Down-0.1437209959
GSE54402Up0.4516523226
GSE9593Down-0.2105039609
GSE43922Up0.3019461879
GSE24585Down-0.1979382166
GSE37065Up0.1501152700
GSE28863_A1Up0.4667228054
GSE28863_A2Up0.4672168370
GSE28863_A3Up0.0149633840
GSE28863_A4Up0.1261194922
GSE48662Down-0.0350540150

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.