HCSGD entry for LEO1

1. General information

Official gene symbolLEO1
Entrez ID123169
Gene full nameLeo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Other gene symbolsRDL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001711Endodermal cell fate commitmentISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006378MRNA polyadenylationIMPbiological_process
GO:0010390Histone monoubiquitinationIDAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016593Cdc73/Paf1 complexIDAcellular_component
GO:0019827Stem cell maintenanceIDAbiological_process
GO:0031442Positive regulation of mRNA 3'-end processingIMPbiological_process
GO:0032968Positive regulation of transcription elongation from RNA polymerase II promoterIDAbiological_process
GO:0033523Histone H2B ubiquitinationIDAbiological_process
GO:0045638Negative regulation of myeloid cell differentiationIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03735821210.92781383310.43640155141.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3323352011
GSE13712_SHEARUp0.1586332620
GSE13712_STATICUp0.0028864493
GSE19018Down-0.3353891848
GSE19899_A1Up0.1534689918
GSE19899_A2Up0.4833968948
PubMed_21979375_A1Up1.3621367020
PubMed_21979375_A2Up0.2438797489
GSE35957Down-0.2074089765
GSE36640Down-0.1437209959
GSE54402Up0.4516523226
GSE9593Down-0.2105039609
GSE43922Up0.3019461879
GSE24585Down-0.1979382166
GSE37065Up0.1501152700
GSE28863_A1Up0.4667228054
GSE28863_A2Up0.4672168370
GSE28863_A3Up0.0149633840
GSE28863_A4Up0.1261194922
GSE48662Down-0.0350540150

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.