HCSGD entry for CLK3

1. General information

Official gene symbolCLK3
Entrez ID1198
Gene full nameCDC-like kinase 3
Other gene symbolsPHCLK3 PHCLK3/152
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001669Acrosomal vesicleIEAcellular_component
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA ISSmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0043484Regulation of RNA splicingIDAbiological_process
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0046777Protein autophosphorylationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08306035860.96454553400.60745532091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0800827543
GSE13712_SHEARDown-0.2120881017
GSE13712_STATICDown-0.0445151449
GSE19018Up0.2532486076
GSE19899_A1Up0.2369844923
GSE19899_A2Up0.6000504744
PubMed_21979375_A1Up0.9218889518
PubMed_21979375_A2Up0.5505079438
GSE35957Down-0.2810206705
GSE36640Up0.1754382527
GSE54402Up0.2192071530
GSE9593Up0.0567222954
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0827414333
GSE28863_A2Down-0.0469920663
GSE28863_A3Up0.3261325799
GSE28863_A4Up0.0354369106
GSE48662Up0.1739143382

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDEDB07664 -
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylateDB08691 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025715SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.