HCSGD entry for CLK3

1. General information

Official gene symbolCLK3
Entrez ID1198
Gene full nameCDC-like kinase 3
Other gene symbolsPHCLK3 PHCLK3/152
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001669Acrosomal vesicleIEAcellular_component
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEA ISSmolecular_function
GO:0004712Protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0004713Protein tyrosine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0016607Nuclear speckIEAcellular_component
GO:0043484Regulation of RNA splicingIDAbiological_process
GO:0045111Intermediate filament cytoskeletonIDAcellular_component
GO:0046777Protein autophosphorylationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08306035860.96454553400.60745532091.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0800827543
GSE13712_SHEARDown-0.2120881017
GSE13712_STATICDown-0.0445151449
GSE19018Up0.2532486076
GSE19899_A1Up0.2369844923
GSE19899_A2Up0.6000504744
PubMed_21979375_A1Up0.9218889518
PubMed_21979375_A2Up0.5505079438
GSE35957Down-0.2810206705
GSE36640Up0.1754382527
GSE54402Up0.2192071530
GSE9593Up0.0567222954
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0827414333
GSE28863_A2Down-0.0469920663
GSE28863_A3Up0.3261325799
GSE28863_A4Up0.0354369106
GSE48662Up0.1739143382

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDEDB07664 -
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylateDB08691 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-7-5pMIMAT0000252MIRT025715SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.