HCSGD entry for CLCN5

1. General information

Official gene symbolCLCN5
Entrez ID1184
Gene full namechloride channel, voltage-sensitive 5
Other gene symbolsCLC5 CLCK2 ClC-5 DENTS NPHL1 NPHL2 XLRH XRN hCIC-K2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0005247Voltage-gated chloride channel activityIEAmolecular_function
GO:0005254Chloride channel activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0007588ExcretionTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0015297Antiporter activityIEAmolecular_function
GO:0016020MembraneIDAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0045177Apical part of cellIDAcellular_component
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02452363510.71281084310.36982026261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1265846387
GSE13712_SHEARDown-0.1957806308
GSE13712_STATICDown-0.0924972704
GSE19018Up0.0091432044
GSE19899_A1Up0.2029144698
GSE19899_A2Up0.1770806348
PubMed_21979375_A1Up0.5094318607
PubMed_21979375_A2Up0.5998832216
GSE35957Up0.8188962297
GSE36640Up0.6440286892
GSE54402Up0.1558412245
GSE9593Up0.2629386994
GSE43922Up0.3884957432
GSE24585Down-0.8154831924
GSE37065Down-0.0734501561
GSE28863_A1Up0.0754114043
GSE28863_A2Up1.5036083261
GSE28863_A3Down-0.6617974884
GSE28863_A4Up0.2260746751
GSE48662Down-0.1738428991

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030774MicroarrayFunctional MTI (Weak)18591254
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.