HCSGD entry for CLCN5

1. General information

Official gene symbolCLCN5
Entrez ID1184
Gene full namechloride channel, voltage-sensitive 5
Other gene symbolsCLC5 CLCK2 ClC-5 DENTS NPHL1 NPHL2 XLRH XRN hCIC-K2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0005247Voltage-gated chloride channel activityIEAmolecular_function
GO:0005254Chloride channel activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006897EndocytosisIEAbiological_process
GO:0007588ExcretionTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0015297Antiporter activityIEAmolecular_function
GO:0016020MembraneIDAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0045177Apical part of cellIDAcellular_component
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02452363510.71281084310.36982026261.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1265846387
GSE13712_SHEARDown-0.1957806308
GSE13712_STATICDown-0.0924972704
GSE19018Up0.0091432044
GSE19899_A1Up0.2029144698
GSE19899_A2Up0.1770806348
PubMed_21979375_A1Up0.5094318607
PubMed_21979375_A2Up0.5998832216
GSE35957Up0.8188962297
GSE36640Up0.6440286892
GSE54402Up0.1558412245
GSE9593Up0.2629386994
GSE43922Up0.3884957432
GSE24585Down-0.8154831924
GSE37065Down-0.0734501561
GSE28863_A1Up0.0754114043
GSE28863_A2Up1.5036083261
GSE28863_A3Down-0.6617974884
GSE28863_A4Up0.2260746751
GSE48662Down-0.1738428991

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT030774MicroarrayFunctional MTI (Weak)18591254
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.