HCSGD entry for CLCN3

1. General information

Official gene symbolCLCN3
Entrez ID1182
Gene full namechloride channel, voltage-sensitive 3
Other gene symbolsCLC3 ClC-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0005247Voltage-gated chloride channel activityIEAmolecular_function
GO:0005254Chloride channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0006810TransportTASbiological_process
GO:0006885Regulation of pHTASbiological_process
GO:0009986Cell surfaceNAScellular_component
GO:0012506Vesicle membraneIDAcellular_component
GO:0015297Antiporter activityIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEA TAScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0030554Adenyl nucleotide bindingIEAmolecular_function
GO:0030658Transport vesicle membraneIEAcellular_component
GO:0031901Early endosome membraneIEAcellular_component
GO:0031902Late endosome membraneIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0044070Regulation of anion transportTASbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048388Endosomal lumen acidificationTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01214747540.88180144370.27561395351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7193755123
GSE13712_SHEARDown-0.1726271934
GSE13712_STATICDown-0.3509272155
GSE19018Down-0.3218586160
GSE19899_A1Up0.3479335736
GSE19899_A2Up0.5484374003
PubMed_21979375_A1Up0.1579846597
PubMed_21979375_A2Up1.2268453524
GSE35957Up0.3361170611
GSE36640Up1.6110723886
GSE54402Up0.6356395701
GSE9593Up0.8496782448
GSE43922Up0.5042441573
GSE24585Up0.0665782133
GSE37065Up0.1036898670
GSE28863_A1Down-0.0262827758
GSE28863_A2Up0.1527152676
GSE28863_A3Down-0.7956817709
GSE28863_A4Down-0.1274085952
GSE48662Down-0.0494639777

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002737Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-335-5pMIMAT0000765MIRT018874MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019489MicroarrayFunctional MTI (Weak)17612493
hsa-miR-548b-3pMIMAT0003254MIRT040507CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.