HCSGD entry for CLCN3

1. General information

Official gene symbolCLCN3
Entrez ID1182
Gene full namechloride channel, voltage-sensitive 3
Other gene symbolsCLC3 ClC-3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0005247Voltage-gated chloride channel activityIEAmolecular_function
GO:0005254Chloride channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005770Late endosomeIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0006810TransportTASbiological_process
GO:0006885Regulation of pHTASbiological_process
GO:0009986Cell surfaceNAScellular_component
GO:0012506Vesicle membraneIDAcellular_component
GO:0015297Antiporter activityIEAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEA TAScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030165PDZ domain bindingIDAmolecular_function
GO:0030554Adenyl nucleotide bindingIEAmolecular_function
GO:0030658Transport vesicle membraneIEAcellular_component
GO:0031901Early endosome membraneIEAcellular_component
GO:0031902Late endosome membraneIEAcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0042803Protein homodimerization activityNASmolecular_function
GO:0044070Regulation of anion transportTASbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048388Endosomal lumen acidificationTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:1902476Chloride transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01214747540.88180144370.27561395351.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7193755123
GSE13712_SHEARDown-0.1726271934
GSE13712_STATICDown-0.3509272155
GSE19018Down-0.3218586160
GSE19899_A1Up0.3479335736
GSE19899_A2Up0.5484374003
PubMed_21979375_A1Up0.1579846597
PubMed_21979375_A2Up1.2268453524
GSE35957Up0.3361170611
GSE36640Up1.6110723886
GSE54402Up0.6356395701
GSE9593Up0.8496782448
GSE43922Up0.5042441573
GSE24585Up0.0665782133
GSE37065Up0.1036898670
GSE28863_A1Down-0.0262827758
GSE28863_A2Up0.1527152676
GSE28863_A3Down-0.7956817709
GSE28863_A4Down-0.1274085952
GSE48662Down-0.0494639777

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002737Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-335-5pMIMAT0000765MIRT018874MicroarrayFunctional MTI (Weak)18185580
hsa-miR-148b-3pMIMAT0000759MIRT019489MicroarrayFunctional MTI (Weak)17612493
hsa-miR-548b-3pMIMAT0003254MIRT040507CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.