HCSGD entry for CHRNA4

1. General information

Official gene symbolCHRNA4
Entrez ID1137
Gene full namecholinergic receptor, nicotinic, alpha 4 (neuronal)
Other gene symbolsBFNC EBN EBN1 NACHR NACHRA4 NACRA4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001508Action potentialISSbiological_process
GO:0001666Response to hypoxiaIDAbiological_process
GO:0004889Acetylcholine-activated cation-selective channel activityIDA IEA TASmolecular_function
GO:0005886Plasma membraneISS TAScellular_component
GO:0005892Acetylcholine-gated channel complexIDAcellular_component
GO:0006281DNA repairIMPbiological_process
GO:0006811Ion transportNASbiological_process
GO:0006816Calcium ion transportISSbiological_process
GO:0006979Response to oxidative stressIMPbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007268Synaptic transmissionNAS TASbiological_process
GO:0007271Synaptic transmission, cholinergicISSbiological_process
GO:0007585Respiratory gaseous exchangeIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0009897External side of plasma membraneISScellular_component
GO:0014059Regulation of dopamine secretionISSbiological_process
GO:0015276Ligand-gated ion channel activityTASmolecular_function
GO:0015464Acetylcholine receptor activityIDAmolecular_function
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0019233Sensory perception of painISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteISScellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035094Response to nicotineIDAbiological_process
GO:0035095Behavioral response to nicotineIMPbiological_process
GO:0035640Exploration behaviorIEAbiological_process
GO:0042113B cell activationISSbiological_process
GO:0042166Acetylcholine bindingICmolecular_function
GO:0042391Regulation of membrane potentialISSbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0050877Neurological system processIMPbiological_process
GO:0050890CognitionIMPbiological_process
GO:0051899Membrane depolarizationISSbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060080Regulation of inhibitory postsynaptic membrane potentialISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46211101400.91308873520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0820792217
GSE13712_SHEARDown-0.0527959365
GSE13712_STATICUp0.0705538881
GSE19018Up0.0613041018
GSE19899_A1Down-0.0428177515
GSE19899_A2Up0.1510426940
PubMed_21979375_A1Up0.0967808112
PubMed_21979375_A2Up0.0110252472
GSE35957Up0.1020299048
GSE36640Up0.0323297997
GSE54402Up0.0513503786
GSE9593Up0.1232152126
GSE43922Up0.1592216086
GSE24585Up0.0147557992
GSE37065Down-0.1744256001
GSE28863_A1Down-0.0216325154
GSE28863_A2Up0.0659771600
GSE28863_A3Up0.3970639888
GSE28863_A4Up0.1542543598
GSE48662Down-0.0118261256

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
TalbutalDB00306 APRD01333
PentobarbitalDB00312 APRD01174
MetharbitalDB00463 APRD00757
DextromethorphanDB00514 APRD00655
GalantamineDB00674 APRD00206 | EXPT01628
PrimidoneDB00794 APRD00549
VareniclineDB01273 -
AmobarbitalDB01351 -
AprobarbitalDB01352 -
ButethalDB01353 -
HeptabarbitalDB01354 -
HexobarbitalDB01355 EXPT03301
BarbitalDB01483 -
Barbituric acid derivativeDB01496 -
ABT-089DB05458 -
RPI-78MDB05740 -
CytisineDB09028 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.