HCSGD entry for CHRNA4

1. General information

Official gene symbolCHRNA4
Entrez ID1137
Gene full namecholinergic receptor, nicotinic, alpha 4 (neuronal)
Other gene symbolsBFNC EBN EBN1 NACHR NACHRA4 NACRA4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001508Action potentialISSbiological_process
GO:0001666Response to hypoxiaIDAbiological_process
GO:0004889Acetylcholine-activated cation-selective channel activityIDA IEA TASmolecular_function
GO:0005886Plasma membraneISS TAScellular_component
GO:0005892Acetylcholine-gated channel complexIDAcellular_component
GO:0006281DNA repairIMPbiological_process
GO:0006811Ion transportNASbiological_process
GO:0006816Calcium ion transportISSbiological_process
GO:0006979Response to oxidative stressIMPbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007268Synaptic transmissionNAS TASbiological_process
GO:0007271Synaptic transmission, cholinergicISSbiological_process
GO:0007585Respiratory gaseous exchangeIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0009897External side of plasma membraneISScellular_component
GO:0014059Regulation of dopamine secretionISSbiological_process
GO:0015276Ligand-gated ion channel activityTASmolecular_function
GO:0015464Acetylcholine receptor activityIDAmolecular_function
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEA NAScellular_component
GO:0019233Sensory perception of painISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteISScellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035094Response to nicotineIDAbiological_process
GO:0035095Behavioral response to nicotineIMPbiological_process
GO:0035640Exploration behaviorIEAbiological_process
GO:0042113B cell activationISSbiological_process
GO:0042166Acetylcholine bindingICmolecular_function
GO:0042391Regulation of membrane potentialISSbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0050877Neurological system processIMPbiological_process
GO:0050890CognitionIMPbiological_process
GO:0051899Membrane depolarizationISSbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060080Regulation of inhibitory postsynaptic membrane potentialISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.46211101400.91308873520.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0820792217
GSE13712_SHEARDown-0.0527959365
GSE13712_STATICUp0.0705538881
GSE19018Up0.0613041018
GSE19899_A1Down-0.0428177515
GSE19899_A2Up0.1510426940
PubMed_21979375_A1Up0.0967808112
PubMed_21979375_A2Up0.0110252472
GSE35957Up0.1020299048
GSE36640Up0.0323297997
GSE54402Up0.0513503786
GSE9593Up0.1232152126
GSE43922Up0.1592216086
GSE24585Up0.0147557992
GSE37065Down-0.1744256001
GSE28863_A1Down-0.0216325154
GSE28863_A2Up0.0659771600
GSE28863_A3Up0.3970639888
GSE28863_A4Up0.1542543598
GSE48662Down-0.0118261256

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
TalbutalDB00306 APRD01333
PentobarbitalDB00312 APRD01174
MetharbitalDB00463 APRD00757
DextromethorphanDB00514 APRD00655
GalantamineDB00674 APRD00206 | EXPT01628
PrimidoneDB00794 APRD00549
VareniclineDB01273 -
AmobarbitalDB01351 -
AprobarbitalDB01352 -
ButethalDB01353 -
HeptabarbitalDB01354 -
HexobarbitalDB01355 EXPT03301
BarbitalDB01483 -
Barbituric acid derivativeDB01496 -
ABT-089DB05458 -
RPI-78MDB05740 -
CytisineDB09028 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.