HCSGD entry for CHRNA3

1. General information

Official gene symbolCHRNA3
Entrez ID1136
Gene full namecholinergic receptor, nicotinic, alpha 3 (neuronal)
Other gene symbolsLNCR2 NACHRA3 PAOD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004889Acetylcholine-activated cation-selective channel activityIDA TASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005892Acetylcholine-gated channel complexIDAcellular_component
GO:0006811Ion transportNASbiological_process
GO:0006812Cation transportIDA TASbiological_process
GO:0006940Regulation of smooth muscle contractionISSbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityISSbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007271Synaptic transmission, cholinergicISSbiological_process
GO:0007399Nervous system developmentIMPbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0014056Regulation of acetylcholine secretion, neurotransmissionISSbiological_process
GO:0014069Postsynaptic densityISScellular_component
GO:0015276Ligand-gated ion channel activityTASmolecular_function
GO:0015464Acetylcholine receptor activityIDAmolecular_function
GO:0016021Integral component of membraneNAScellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteISScellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035095Behavioral response to nicotineIMPbiological_process
GO:0042166Acetylcholine bindingICmolecular_function
GO:0042391Regulation of membrane potentialISSbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0048814Regulation of dendrite morphogenesisISSbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialISSbiological_process
GO:0060084Synaptic transmission involved in micturitionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74221950150.69946911590.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0865512867
GSE13712_SHEARDown-0.0148602469
GSE13712_STATICDown-0.1353432192
GSE19018Up0.0827701123
GSE19899_A1Up0.0990083047
GSE19899_A2Up0.0043091880
PubMed_21979375_A1Down-0.2484502276
PubMed_21979375_A2Down-0.2735444973
GSE35957Up0.1523978037
GSE36640Down-0.1301888123
GSE54402Up0.0191318721
GSE9593Down-0.0525772676
GSE43922Down-0.0182462367
GSE24585Up0.2189006362
GSE37065Up0.2206849513
GSE28863_A1Down-0.1915867272
GSE28863_A2Down-0.1080903897
GSE28863_A3Up0.3149321375
GSE28863_A4Up0.0007822060
GSE48662Up0.0693526373

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
DextromethorphanDB00514 APRD00655
GalantamineDB00674 APRD00206 | EXPT01628
LevamisoleDB00848 APRD01067
PentoliniumDB01090 APRD00038
BupropionDB01156 APRD00621
VareniclineDB01273 -
CytisineDB09028 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.