HCSGD entry for CHRNA3

1. General information

Official gene symbolCHRNA3
Entrez ID1136
Gene full namecholinergic receptor, nicotinic, alpha 3 (neuronal)
Other gene symbolsLNCR2 NACHRA3 PAOD2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004889Acetylcholine-activated cation-selective channel activityIDA TASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005892Acetylcholine-gated channel complexIDAcellular_component
GO:0006811Ion transportNASbiological_process
GO:0006812Cation transportIDA TASbiological_process
GO:0006940Regulation of smooth muscle contractionISSbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007171Activation of transmembrane receptor protein tyrosine kinase activityISSbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007271Synaptic transmission, cholinergicISSbiological_process
GO:0007399Nervous system developmentIMPbiological_process
GO:0007626Locomotory behaviorISSbiological_process
GO:0014056Regulation of acetylcholine secretion, neurotransmissionISSbiological_process
GO:0014069Postsynaptic densityISScellular_component
GO:0015276Ligand-gated ion channel activityTASmolecular_function
GO:0015464Acetylcholine receptor activityIDAmolecular_function
GO:0016021Integral component of membraneNAScellular_component
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteISScellular_component
GO:0034220Ion transmembrane transportIDA TASbiological_process
GO:0035095Behavioral response to nicotineIMPbiological_process
GO:0042166Acetylcholine bindingICmolecular_function
GO:0042391Regulation of membrane potentialISSbiological_process
GO:0043025Neuronal cell bodyISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0048814Regulation of dendrite morphogenesisISSbiological_process
GO:0055085Transmembrane transportIDA TASbiological_process
GO:0060079Regulation of excitatory postsynaptic membrane potentialISSbiological_process
GO:0060084Synaptic transmission involved in micturitionIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.74221950150.69946911590.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0865512867
GSE13712_SHEARDown-0.0148602469
GSE13712_STATICDown-0.1353432192
GSE19018Up0.0827701123
GSE19899_A1Up0.0990083047
GSE19899_A2Up0.0043091880
PubMed_21979375_A1Down-0.2484502276
PubMed_21979375_A2Down-0.2735444973
GSE35957Up0.1523978037
GSE36640Down-0.1301888123
GSE54402Up0.0191318721
GSE9593Down-0.0525772676
GSE43922Down-0.0182462367
GSE24585Up0.2189006362
GSE37065Up0.2206849513
GSE28863_A1Down-0.1915867272
GSE28863_A2Down-0.1080903897
GSE28863_A3Up0.3149321375
GSE28863_A4Up0.0007822060
GSE48662Up0.0693526373

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicotineDB00184 APRD00200 | EXPT02315 | DB09463
DextromethorphanDB00514 APRD00655
GalantamineDB00674 APRD00206 | EXPT01628
LevamisoleDB00848 APRD01067
PentoliniumDB01090 APRD00038
BupropionDB01156 APRD00621
VareniclineDB01273 -
CytisineDB09028 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.