HCSGD entry for AKAP13

1. General information

Official gene symbolAKAP13
Entrez ID11214
Gene full nameA kinase (PRKA) anchor protein 13
Other gene symbolsAKAP-13 AKAP-Lbc ARHGEF13 BRX HA-3 Ht31 LBC PRKA13 PROTO-LB PROTO-LBC c-lbc p47
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004691CAMP-dependent protein kinase activityNASmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008152Metabolic processNASbiological_process
GO:0010611Regulation of cardiac muscle hypertrophyIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0016310PhosphorylationNASbiological_process
GO:0017048Rho GTPase bindingIEAmolecular_function
GO:0032947Protein complex scaffoldIEAmolecular_function
GO:0035556Intracellular signal transductionIEAbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0045859Regulation of protein kinase activityIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051018Protein kinase A bindingIEAmolecular_function
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0051168Nuclear exportIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:1900169Regulation of glucocorticoid mediated signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10551863530.92950803920.67460675251.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0239915354
GSE13712_SHEARDown-0.1739960793
GSE13712_STATICDown-0.0676225238
GSE19018Up0.0677991127
GSE19899_A1Down-0.0157264367
GSE19899_A2Down-0.1820145655
PubMed_21979375_A1Down-0.1838614062
PubMed_21979375_A2Up0.0801944214
GSE35957Up0.1628702776
GSE36640Down-0.3352842784
GSE54402Up0.1707309198
GSE9593Up0.1942152440
GSE43922Up0.0486532994
GSE24585Up0.3379729142
GSE37065Up0.2743351574
GSE28863_A1Up0.8795415481
GSE28863_A2Up0.7968050166
GSE28863_A3Down-0.0722740120
GSE28863_A4Up0.0630239265
GSE48662Up0.2831006286

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017303MicroarrayFunctional MTI (Weak)18185580
hsa-miR-423-5pMIMAT0004748MIRT038038CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041492CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042150CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045632CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051060CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.