HCSGD entry for AKAP13
1. General information
| Official gene symbol | AKAP13 |
|---|---|
| Entrez ID | 11214 |
| Gene full name | A kinase (PRKA) anchor protein 13 |
| Other gene symbols | AKAP-13 AKAP-Lbc ARHGEF13 BRX HA-3 Ht31 LBC PRKA13 PROTO-LB PROTO-LBC c-lbc p47 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004691 | CAMP-dependent protein kinase activity | NAS | molecular_function |
| GO:0004871 | Signal transducer activity | TAS | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0008152 | Metabolic process | NAS | biological_process |
| GO:0010611 | Regulation of cardiac muscle hypertrophy | IEA | biological_process |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0016310 | Phosphorylation | NAS | biological_process |
| GO:0017048 | Rho GTPase binding | IEA | molecular_function |
| GO:0032947 | Protein complex scaffold | IEA | molecular_function |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0045859 | Regulation of protein kinase activity | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051018 | Protein kinase A binding | IEA | molecular_function |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0051168 | Nuclear export | IEA | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
| GO:1900169 | Regulation of glucocorticoid mediated signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1055186353 | 0.9295080392 | 0.6746067525 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0239915354 |
| GSE13712_SHEAR | Down | -0.1739960793 |
| GSE13712_STATIC | Down | -0.0676225238 |
| GSE19018 | Up | 0.0677991127 |
| GSE19899_A1 | Down | -0.0157264367 |
| GSE19899_A2 | Down | -0.1820145655 |
| PubMed_21979375_A1 | Down | -0.1838614062 |
| PubMed_21979375_A2 | Up | 0.0801944214 |
| GSE35957 | Up | 0.1628702776 |
| GSE36640 | Down | -0.3352842784 |
| GSE54402 | Up | 0.1707309198 |
| GSE9593 | Up | 0.1942152440 |
| GSE43922 | Up | 0.0486532994 |
| GSE24585 | Up | 0.3379729142 |
| GSE37065 | Up | 0.2743351574 |
| GSE28863_A1 | Up | 0.8795415481 |
| GSE28863_A2 | Up | 0.7968050166 |
| GSE28863_A3 | Down | -0.0722740120 |
| GSE28863_A4 | Up | 0.0630239265 |
| GSE48662 | Up | 0.2831006286 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017303 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038038 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041492 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042150 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045632 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051060 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
