HCSGD entry for CHKA

1. General information

Official gene symbolCHKA
Entrez ID1119
Gene full namecholine kinase alpha
Other gene symbolsCHK CK CKI EK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004103Choline kinase activityIDAmolecular_function
GO:0004104Cholinesterase activityIEAmolecular_function
GO:0004305Ethanolamine kinase activityIDAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0006629Lipid metabolic processTASbiological_process
GO:0006644Phospholipid metabolic processTASbiological_process
GO:0006646Phosphatidylethanolamine biosynthetic processIDA IEA TASbiological_process
GO:0006656Phosphatidylcholine biosynthetic processIDA TASbiological_process
GO:0006657CDP-choline pathwayIDA TASbiological_process
GO:0006869Lipid transportTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0016301Kinase activityIEAmolecular_function
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0019695Choline metabolic processIEAbiological_process
GO:0033265Choline bindingIEAmolecular_function
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046474Glycerophospholipid biosynthetic processIEA TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30413361190.51719393640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2911759044
GSE13712_SHEARDown-0.2944579427
GSE13712_STATICDown-0.2715411345
GSE19018Down-0.0241976527
GSE19899_A1Down-0.1403928892
GSE19899_A2Up0.1293974676
PubMed_21979375_A1Up0.4171643881
PubMed_21979375_A2Down-0.0429519838
GSE35957Down-0.7657479027
GSE36640Down-0.5508175205
GSE54402Up0.1213336019
GSE9593Down-0.0159940686
GSE43922Up0.0467635690
GSE24585Up0.2707622991
GSE37065Up0.2943857398
GSE28863_A1Up0.0760730729
GSE28863_A2Up0.5771686844
GSE28863_A3Down-0.1552326459
GSE28863_A4Up0.0240263459
GSE48662Up0.0504608022

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1909970CHEMBL31179P35790
CHEMBL1909974CHEMBL31179P35790
CHEMBL1909959CHEMBL31179P35790
CHEMBL1909972CHEMBL31179P35790
CHEMBL1909963CHEMBL31179P35790
CHEMBL1909965CHEMBL31179P35790
CHEMBL1909968CHEMBL31179P35790
CHEMBL1909962CHEMBL31179P35790
CHEMBL1909964CHEMBL31179P35790
CHEMBL1909961CHEMBL31179P35790
CHEMBL1909958CHEMBL31179P35790
CHEMBL1909973CHEMBL31179P35790
CHEMBL1909969CHEMBL31179P35790
CHEMBL1909966CHEMBL31179P35790
CHEMBL1771556CHEMBL31178P35790
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  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23466301Senescence suppresses development of tumors by regulating aging factors, such as cyclin dependent kinase inhibitor (CKI) and telomerase
19486941A number of studies suggest that interactions of ROS with the G1 CDK/CKI network play a fundamental role in senescence, which is considered a barrier to tumorigenesis
16234365Hematopoietic exhaustion appears to be accelerated in the absence of p21(Cip1/Waf1) (p21), a cyclin-dependent kinase inhibitor (CKI) in irradiated hosts
11389930In addition, at the end of their lifespans, the T cell clones did not display the CKI phenotype reported for senescent cells (an increase in p16 and p21 levels)
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